| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C110216-100mg |
100mg |
现货  |
|
| 英文别名 | Catalpol | CHEBI:69797 | SR-05000002315-2 | (2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol | beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hyd |
|---|---|
| 规格或纯度 | ≥97%(HPLC) |
| 英文名称 | Catalpol |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
主要功能是刺激肾上腺皮质激素的生产，从而增加了生产性荷尔蒙。梓醇也具有抗发炎活性，并已证实会增加肾上腺产生的雄性激素的生产，从而导致肌肉块增大。 |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 488186660 |
|---|---|
| EC号 | 219-324-0 |
| 分子类型 | 小分子 |
| IUPAC Name | (2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| INCHI | InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1 |
| InChi Key | LHDWRKICQLTVDL-PZYDOOQISA-N |
| Canonical SMILES | C1=COC(C2C1C(C3C2(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O |
| Isomeric SMILES | C1=CO[C@H]([C@H]2[C@@H]1[C@@H]([C@H]3[C@@]2(O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O |
| WGK Germany | 3 |
| RTECS | LZ5776816 |
| PubChem CID | 91520 |
| 分子量 | 362.33 |
| 密度 | 1.72 |
|---|---|
| 分子量 | 362.330 g/mol |
| XLogP3 | -3.200 |
| 氢键供体数Hydrogen Bond Donor Count | 6 |
| 氢键受体数Hydrogen Bond Acceptor Count | 10 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 362.121 Da |
| 单同位素质量Monoisotopic Mass | 362.121 Da |
| 拓扑极表面积Topological Polar Surface Area | 162.000 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 542.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 11 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | LZ5776816 |
| Purity(HPLC) | 97-100（%） |
|---|---|
| Appearance（C110216) | White to Off-White Solid, Powder, or Crystals |
| Proton NMR spectrum | Conforms to Structure |
| 1. Jiaquan Xu, Zhendong Yu, Ting Li, Lili Song, Zi-Dong Qiu, Luqi Huang, Huanwen Chen, Hui Li. (2023) Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 34 (7): (1342–1348). [PMID:37294877] [10.1021/jasms.3c00043] |
| 2. Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang, Jing Li. (2021) Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways. Bioengineered, 12 (1): (183-195). [PMID:33323018] [10.1080/21655979.2020.1863015] |
| 3. Mengqiao Lian, Yuchao Sun, Yuan Lin, Jin Wen, Marwan Almoiliqy, Bin Xu, Yanli Li, Ming Xu, Dapeng Chen, Zeyao Tang, Li Wang. (2017) p-JAK2 plays a key role in catalpol-induced protection against rat intestinal ischemia/reperfusion injury. RSC Advances, 7 (86): (54369-54378). [10.1039/C7RA10506A] |
| 4. Jin Di, Cao Ming, Mu Xin, Yang Guoliang, Xue Wei, Huang Yiran, Chen Haige. (2015) Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling. CELL BIOCHEMISTRY AND BIOPHYSICS, 71 (3): (1349-1356). [PMID:25388838] [10.1007/s12013-014-0355-0] |
| 1. Jiaquan Xu, Zhendong Yu, Ting Li, Lili Song, Zi-Dong Qiu, Luqi Huang, Huanwen Chen, Hui Li. (2023) Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 34 (7): (1342–1348). [PMID:37294877] [10.1021/jasms.3c00043] |
| 2. Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang, Jing Li. (2021) Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways. Bioengineered, 12 (1): (183-195). [PMID:33323018] [10.1080/21655979.2020.1863015] |
| 3. Mengqiao Lian, Yuchao Sun, Yuan Lin, Jin Wen, Marwan Almoiliqy, Bin Xu, Yanli Li, Ming Xu, Dapeng Chen, Zeyao Tang, Li Wang. (2017) p-JAK2 plays a key role in catalpol-induced protection against rat intestinal ischemia/reperfusion injury. RSC Advances, 7 (86): (54369-54378). [10.1039/C7RA10506A] |
| 4. Jin Di, Cao Ming, Mu Xin, Yang Guoliang, Xue Wei, Huang Yiran, Chen Haige. (2015) Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling. CELL BIOCHEMISTRY AND BIOPHYSICS, 71 (3): (1349-1356). [PMID:25388838] [10.1007/s12013-014-0355-0] |
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