页面 4 | mTOR - PI3K/Akt/mTOR 信号通路 - 按“信号通路”分类

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GSK1059615,PI 3-激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 958852-01-2 Compound CID : 23582824

分子式: C₁₈H₁₁N₃O₂S 分子量: 333.36

IUPAC Name: (5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione

SMILES: C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4

InChIKey: QDITZBLZQQZVEE-YBEGLDIGSA-N

InChI: InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-

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GDC-0980 (RG7422)

规格或纯度 :

Moligand™

≥98%

CAS号 : 1032754-93-0 Compound CID : 25254071

分子式: C₂₃H₃₀N₈O₃S 分子量: 498.61

IUPAC Name: (2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

SMILES: CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O

InChIKey: YOVVNQKCSKSHKT-HNNXBMFYSA-N

InChI: InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1

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GSK2126458(GSK458),PI3激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1086062-66-9 Compound CID : 25167777

分子式: C₂₅H₁₇F₂N₅O₃S 分子量: 505.5

IUPAC Name: 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide

SMILES: COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F

InChIKey: CGBJSGAELGCMKE-UHFFFAOYSA-N

InChI: InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3

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INK 128 (MLN0128),mTOR抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1224844-38-5 Compound CID : 45375953

分子式: C₁₅H₁₅N₇O 分子量: 309.33

IUPAC Name: 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine

SMILES: CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N

InChIKey: GYLDXIAOMVERTK-UHFFFAOYSA-N

InChI: InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)

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KU-0063794,mTOR抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 938440-64-3 Compound CID : 16736978

分子式: C₂₅H₃₁N₅O₄ 分子量: 465.54

IUPAC Name: [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

SMILES: CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5

InChIKey: RFSMUFRPPYDYRD-CALCHBBNSA-N

InChI: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+

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KU-0060648,DNA-PK和PI 3-K双重抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 881375-00-4 Compound CID : 11964036

分子式: C₃₃H₃₄N₄O₄S 分子量: 582.71

IUPAC Name: 2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide

SMILES: CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

InChIKey: AATCBLYHOUOCTO-UHFFFAOYSA-N

InChI: InChI=1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11,20H,2,12-19,21H2,1H3,(H,34,39)

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L-亮氨酸

规格或纯度 :

Moligand™

≥99%

CAS号 : 61-90-5

分子式: C₆H₁₃NO₂ 分子量: 131.17

IUPAC Name: (2S)-2-amino-4-methylpentanoic acid

SMILES: CC(C)CC(C(=O)O)N

InChIKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N

InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

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L-亮氨酸-15N

规格或纯度 :

≥98 atom%,≥98%

CAS号 : 59935-31-8 Compound CID : 10329327

分子式: C₆H₁₂15NO₂ 分子量: 132.17

IUPAC Name: (2S)-2-(15N)azanyl-4-methylpentanoic acid

SMILES: CC(C)CC(C(=O)O)N

InChIKey: ROHFNLRQFUQHCH-GEERXGHESA-N

InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i7+1

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瑞香素

规格或纯度 :

≥90%(HPLC)

CAS号 : 486-35-1 Compound CID : 5280569

分子式: C₉H₆O₄ 分子量: 178.14

IUPAC Name: 7,8-dihydroxychromen-2-one

SMILES: C1=CC(=C(C2=C1C=CC(=O)O2)O)O

InChIKey: ATEFPOUAMCWAQS-UHFFFAOYSA-N

InChI: InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

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双环醇

规格或纯度 :

≥98%(HPLC)

CAS号 : 118159-48-1 Compound CID : 9821754

分子式: C₁₉H₁₈O₉ 分子量: 390.34

IUPAC Name: methyl 4-[5-(hydroxymethyl)-7-methoxy-1,3-benzodioxol-4-yl]-7-methoxy-1,3-benzodioxole-5-carboxylate

SMILES: COC1=C2C(=C(C(=C1)CO)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2

InChIKey: KXMTXZACPVCDMH-UHFFFAOYSA-N

InChI: InChI=1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3

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二氢杨梅素

规格或纯度 :

Moligand™

≥97%(HPLC)

CAS号 : 27200-12-0 Compound CID : 161557

分子式: C₁₅H₁₂O₈ 分子量: 320.25

IUPAC Name: (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

SMILES: C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O

InChIKey: KJXSIXMJHKAJOD-LSDHHAIUSA-N

InChI: InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1

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苍术苷钾盐

规格或纯度 :

Moligand™

≥98%

CAS号 : 102130-43-8 Compound CID : 12299879

分子式: C₃₀H₄₄K₂O₁₆S₂ 分子量: 802.99

IUPAC Name: dipotassium;[(2S,3R,4R,5R,6R)-2-[[(1R,4R,5R,7R,9R,10S,13R,15S)-5-carboxy-15-hydroxy-9-methyl-14-methylidene-7-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]oxy]-6-(hydroxymethyl)-3-(3-methylbutanoyloxy)-5-sulfonatooxyoxan-4-yl] sulfate

SMILES: CC(C)CC(=O)OC1C(C(C(OC1OC2CC(C3CCC45CC(CCC4C3(C2)C)C(=C)C5O)C(=O)O)CO)OS(=O)(=O)[O-])OS(=O)(=O)[O-].[K+].[K+]

InChIKey: IUCNQFHEWLYECJ-VCQILIGCSA-L

InChI: InChI=1S/C30H46O16S2.2K/c1-14(2)9-22(32)44-25-24(46-48(39,40)41)23(45-47(36,37)38)20(13-31)43-28(25)42-17-10-18(27(34)35)19-7-8-30-11-16(15(3)26(30)33)5-6-21(30)29(19,4)12-17;;/h14,16-21,23-26,28,31,33H,3,5-13H2,1-2,4H3,(H,34,35)(H,36,37,38)(H,39,40,41);;/q;2*+1/p-2/t16-,17-,18-,19-,20-,21+,23-,24+,25-,26+,28+,29-,30-;;/m1../s1

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