页面 3 | Epigenetic Reader Domain - 表观遗传学 - 按“信号通路”分类

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PFI-3,bromodomain 和SMARCA4抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1819363-80-8 Compound CID : 78243717

分子式: C₁₉H₁₉N₃O₂ 分子量: 321.4

IUPAC Name: (E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one

SMILES: C1C2CN(C1CN2C3=CC=CC=N3)C=CC(=O)C4=CC=CC=C4O

InChIKey: INAICWLVUAKEPB-QSTFCLMHSA-N

InChI: InChI=1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1

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GSK6853,BRPF1溴结构域抑制剂

规格或纯度 :

≥98%

CAS号 : 1910124-24-1 Compound CID : 121232405

分子式: C₂₂H₂₇N₅O₃ 分子量: 409.48

IUPAC Name: N-[1,3-dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide

SMILES: CC1CNCCN1C2=CC3=C(C=C2NC(=O)C4=CC=CC=C4OC)N(C(=O)N3C)C

InChIKey: FQWDVNSBYDXPIO-CQSZACIVSA-N

InChI: InChI=1S/C22H27N5O3/c1-14-13-23-9-10-27(14)17-12-19-18(25(2)22(29)26(19)3)11-16(17)24-21(28)15-7-5-6-8-20(15)30-4/h5-8,11-12,14,23H,9-10,13H2,1-4H3,(H,24,28)/t14-/m1/s1

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Mz1,（+）-JQ1基PROTAC降解BRD4

规格或纯度 :

Moligand™

≥98%

CAS号 : 1797406-69-9 Compound CID : 122201421

分子式: C₄₉H₆₀ClN₉O₈S₂ 分子量: 1002.64

IUPAC Name: (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C

InChIKey: PTAMRJLIOCHJMQ-PYNGZGNASA-N

InChI: InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1

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Compound 3i (666-15)

规格或纯度 :

≥98%

CAS号 : 1433286-70-4 Compound CID : 71566396

分子式: C₃₃H₃₀ClN₃O₅·HCl 分子量: 620.5

IUPAC Name: 3-(3-aminopropoxy)-N-[2-[3-[(4-chloro-2-hydroxyphenyl)carbamoyl]naphthalen-2-yl]oxyethyl]naphthalene-2-carboxamide;hydrochloride

SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NCCOC3=CC4=CC=CC=C4C=C3C(=O)NC5=C(C=C(C=C5)Cl)O)OCCCN.Cl

InChIKey: LELLCPHHYHLWBH-UHFFFAOYSA-N

InChI: InChI=1S/C33H30ClN3O5.ClH/c34-25-10-11-28(29(38)20-25)37-33(40)27-17-22-7-2-4-9-24(22)19-31(27)42-15-13-36-32(39)26-16-21-6-1-3-8-23(21)18-30(26)41-14-5-12-35;/h1-4,6-11,16-20,38H,5,12-15,35H2,(H,36,39)(H,37,40);1H

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PFI 4,BRPF1B溴结构域抑制剂

规格或纯度 :

Moligand™

≥97%

CAS号 : 900305-37-5 Compound CID : 40642506

分子式: C₂₁H₂₄N₄O₃ 分子量: 380.44

IUPAC Name: N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide

SMILES: CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCC4)N(C1=O)C

InChIKey: QCIJLRJBZDBVDB-UHFFFAOYSA-N

InChI: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)

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PF CBP1,CBP / p300溴结构域抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号 : 1962928-21-7 Compound CID : 119081417

分子式: C₂₉H₃₆N₄O₃ 分子量: 488.62

IUPAC Name: 4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine

SMILES: CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C

InChIKey: CGWBJJZOKGZCSJ-UHFFFAOYSA-N

InChI: InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3

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OXF BD 02,BRD4（1）抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号 : 1429129-68-9 Compound CID : 56929801

分子式: C₁₈H₁₇NO₃ 分子量: 295.33

IUPAC Name: 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(phenyl)methyl]phenol

SMILES: CC1=C(C(=NO1)C)C2=CC(=CC(=C2)O)C(C3=CC=CC=C3)O

InChIKey: FEQUIPXIENTMJN-UHFFFAOYSA-N

InChI: InChI=1S/C18H17NO3/c1-11-17(12(2)22-19-11)14-8-15(10-16(20)9-14)18(21)13-6-4-3-5-7-13/h3-10,18,20-21H,1-2H3

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OF 1,BRPF1B和BRPF2抑制剂

规格或纯度 :

Moligand™

≥98%(HPLC)

CAS号 : 919973-83-4 Compound CID : 35397514

分子式: C₁₇H₁₈BrN₃O₄S 分子量: 440.31

IUPAC Name: 4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide

SMILES: CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=CC3=C(C=C2OC)N(C(=O)N3C)C

InChIKey: YUNQZQREIHWDQT-UHFFFAOYSA-N

InChI: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3

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NVS-CECR2-1,CECR2抑制剂

规格或纯度 :

Moligand™

≥98%(HPLC)

CAS号 : 1992047-61-6 Compound CID : 117072550

分子式: C₂₇H₃₇N₅O₂S 分子量: 495.68

IUPAC Name: N-cyclopropyl-2-propylsulfonyl-6-[1-(2,2,6,6-tetramethylpiperidin-4-yl)indol-5-yl]pyrimidin-4-amine

SMILES: CCCS(=O)(=O)C1=NC(=CC(=N1)NC2CC2)C3=CC4=C(C=C3)N(C=C4)C5CC(NC(C5)(C)C)(C)C

InChIKey: XVECNLUKQDKOST-UHFFFAOYSA-N

InChI: InChI=1S/C27H37N5O2S/c1-6-13-35(33,34)25-29-22(15-24(30-25)28-20-8-9-20)18-7-10-23-19(14-18)11-12-32(23)21-16-26(2,3)31-27(4,5)17-21/h7,10-12,14-15,20-21,31H,6,8-9,13,16-17H2,1-5H3,(H,28,29,30)

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NI 42,BRPF抑制剂

规格或纯度 :

≥98%

CAS号 : 1884640-99-6 Compound CID : 118933132

分子式: C₁₈H₁₅N₃O₃S 分子量: 353.39

IUPAC Name: 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)benzenesulfonamide

SMILES: CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)C#N)N(C1=O)C

InChIKey: BMVCSXFOQPYKKC-UHFFFAOYSA-N

InChI: InChI=1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3

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MS 436,BRD4（1）抑制剂

规格或纯度 :

Moligand™

≥95%

CAS号 : 1395084-25-9 Compound CID : 135566899

分子式: C₁₈H₁₇N₅O₃S 分子量: 383.42

IUPAC Name: 4-[(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamide

SMILES: CC1=CC(=C(C=C1O)N)N=NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3

InChIKey: DZTGIRNXWSZBIM-UHFFFAOYSA-N

InChI: InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)

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LP 99,BRD7和BRD9抑制剂

规格或纯度 :

Moligand™

≥98%(HPLC)

CAS号 : 1808951-93-0 Compound CID : 91827372

分子式: C₂₆H₃₀ClN₃O₄S 分子量: 516.05

IUPAC Name: N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide

SMILES: CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C

InChIKey: LVDRREOUMKACNJ-BKMJKUGQSA-N

InChI: InChI=1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1

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