| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B426441-1ml |
1ml |
现货  |
|
| 英文别名 | benazepril | 86541-75-5 | Benazeprilum | Benazeprilum [Latin] | Lotrel | Benazepril Sandoz | Forteekor | CGS-14824A | Cibacen ws | CGS-14824-A | UNII-UDM7Q7QWP8 | UDM7Q7QWP8 | Benazepril (INN) | CHEBI:3011 | 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Benazepril Free base |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 血管紧张素转换酶抑制剂 |
| 产品介绍 |
贝那普利游离碱是ACE（血管紧张素转换酶）的抑制剂。这阻止了血管紧张素I向血管紧张素II的转化，继而阻止了与血管紧张素II受体活化相关的血管收缩。ACE抑制导致血管扩张和毛细血管血容量增加。 Benazepril Free base is an inhibitor of ACE (angiotensin-converting enzyme). This blocks the conversion of angiotensin I to angiotensin II, which in turn prevents vasoconstriction associated with activation of angiotensin II receptors. ACE inhibition causes vasodilation and an increase in capillary blood volume. |
| pKa值 | pKₐ: 3.73 (Predicted), pKₐ: 5.27 (Predicted) |
|---|---|
| IC50 | ACE: IC₅₀= 1.7 nM (human) |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid |
| INCHI | InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 |
| InChi Key | XPCFTKFZXHTYIP-PMACEKPBSA-N |
| Canonical SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O |
| Isomeric SMILES | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O |
| PubChem CID | 5362124 |
| 分子量 | 424.49 |
| 折光率 | n20D1.61 (Predicted) |
|---|---|
| 沸点 | ~691.2° C at 760 mmHg (Predicted) |
| 熔点 | 148.5° C |
| 分子量 | 424.500 g/mol |
| XLogP3 | 1.300 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 10 |
| 精确质量Exact Mass | 424.2 Da |
| 单同位素质量Monoisotopic Mass | 424.2 Da |
| 拓扑极表面积Topological Polar Surface Area | 95.900 Ų |
| 重原子数Heavy Atom Count | 31 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 619.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration(Compounding value) | |
|---|---|
| Record the entire process by video | conform |
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