| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B425736-1ml |
1ml |
现货  |
|
| 别名 | 4,4'-二甲氧基-5,6,5',6'-双亚甲二氧联苯-2,2'-二甲酸二甲酯 | 联苯双酯 |
|---|---|
| 英文别名 | BDBM50289527 | Tox21_303479 | UNII-0G32E321W1 | 7,7'-Dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester | Dimethyl 7,7 inverted exclamation mark -Dimethoxy-[4,4 inverted exclamation mark -bi-1,3-benzodioxole]-5,5 inverted exclamati |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Bifendatatum |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | methyl 7-methoxy-4-(7-methoxy-5-methoxycarbonyl-1,3-benzodioxol-4-yl)-1,3-benzodioxole-5-carboxylate |
| INCHI | InChI=1S/C20H18O10/c1-23-11-5-9(19(21)25-3)13(17-15(11)27-7-29-17)14-10(20(22)26-4)6-12(24-2)16-18(14)30-8-28-16/h5-6H,7-8H2,1-4H3 |
| InChi Key | JMZOMFYRADAWOG-UHFFFAOYSA-N |
| Canonical SMILES | COC1=C2C(=C(C(=C1)C(=O)OC)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2 |
| Isomeric SMILES | COC1=C2C(=C(C(=C1)C(=O)OC)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2 |
| 关联CAS | 73536-69-3 |
| PubChem CID | 108213 |
| MeSH Entry Terms | 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester;alpha-diphenyldicarboxylate;BDD;biphenyl dimethyl-dicarboxylate;dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate;dimethyl diphenyl bicarboxylate;d |
| 分子量 | 418.4 |
| 敏感性 | 对空气敏感，对热敏感 |
|---|---|
| 熔点 | 181 °C |
| 分子量 | 418.300 g/mol |
| XLogP3 | 2.800 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 10 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 418.09 Da |
| 单同位素质量Monoisotopic Mass | 418.09 Da |
| 拓扑极表面积Topological Polar Surface Area | 108.000 Ų |
| 重原子数Heavy Atom Count | 30 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 587.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration(Compounding value) | |
|---|---|
| Record the entire process by video | conform |
| 1. Peng Lei, Zhirong Zhou, Jierong Pei, Li Jia, Lifeng Han, Miaomiao Jiang. (2024) Extraction process optimization of alisol B 23-acetate from Alismatis Rhizoma and its protection against carbon tetrachloride-induced acute liver injury. Arabian Journal of Chemistry, 17 (15): (105479). [PMID:16215984] [10.1016/j.arabjc.2023.105479] |
| 2. Weigang Yuan, Fenglei Jian, Yueguang Rong. (2022) Bifendate inhibits autophagy at multiple steps and attenuates oleic acid-induced lipid accumulation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 631 (115). [PMID:36183552] [10.1016/j.bbrc.2022.09.067] |
| 3. Yang Xin-Bin, Huang Yu. (2020) Protective effects of apigenin, apigenin-8-sulfonate, and apigenin-3′, 8-disulfonate on d-galactosamine-induced acute liver damage in mice. MEDICINAL CHEMISTRY RESEARCH, 29 (10): (1867-1873). [10.1007/s00044-020-02608-2] |
| 4. Yue Shuwen, Xue Ning, Li Honglei, Huang Baosheng, Chen Zhen, Wang Xing. (2020) Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro. INFLAMMATION, 43 (5): (1634-1648). [PMID:32458347] [10.1007/s10753-020-01238-5] |
| 5. Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang. (2017) Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 122 (3): (331-340). [PMID:28945011] [10.1111/bcpt.12914] |
| 1. Peng Lei, Zhirong Zhou, Jierong Pei, Li Jia, Lifeng Han, Miaomiao Jiang. (2024) Extraction process optimization of alisol B 23-acetate from Alismatis Rhizoma and its protection against carbon tetrachloride-induced acute liver injury. Arabian Journal of Chemistry, 17 (15): (105479). [PMID:16215984] [10.1016/j.arabjc.2023.105479] |
| 2. Weigang Yuan, Fenglei Jian, Yueguang Rong. (2022) Bifendate inhibits autophagy at multiple steps and attenuates oleic acid-induced lipid accumulation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 631 (115). [PMID:36183552] [10.1016/j.bbrc.2022.09.067] |
| 3. Yang Xin-Bin, Huang Yu. (2020) Protective effects of apigenin, apigenin-8-sulfonate, and apigenin-3′, 8-disulfonate on d-galactosamine-induced acute liver damage in mice. MEDICINAL CHEMISTRY RESEARCH, 29 (10): (1867-1873). [10.1007/s00044-020-02608-2] |
| 4. Yue Shuwen, Xue Ning, Li Honglei, Huang Baosheng, Chen Zhen, Wang Xing. (2020) Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro. INFLAMMATION, 43 (5): (1634-1648). [PMID:32458347] [10.1007/s10753-020-01238-5] |
| 5. Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang. (2017) Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 122 (3): (331-340). [PMID:28945011] [10.1111/bcpt.12914] |
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