计算溶液所需的质量、体积或浓度。
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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A657418-250mg |
250mg |
现货 ![]() |
| |
A657418-1g |
1g |
现货 ![]() |
| |
A657418-5g |
5g |
现货 ![]() |
|
别名 | Fungizone; Amphotericin B from Streptomyces sp; Amphotericin B solubilized |
---|---|
英文别名 | Fungizone; Amphotericin B from Streptomyces sp; Amphotericin B solubilized |
规格或纯度 | 无动物源, Low Endotoxin, 用于细胞培养, ≥750 μg/mg |
英文名称 | Amphotericin B |
生化机理 | 抗霉菌多烯。通过靶向固醇(如麦角固醇)破坏真菌细胞膜的通透性。体内具有活性 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
作用类型 | 多价螯合剂 |
作用机制 | 麦角甾醇螯合剂 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
溶于DMSO,水中溶解度:<0.1 g/100 mL ,21°C |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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EC号 | 231-791-2 |
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分子类型 | 小分子 |
IUPAC Name | (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid |
INCHI | InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1 |
InChi Key | APKFDSVGJQXUKY-INPOYWNPSA-N |
Canonical SMILES | CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O |
Isomeric SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
PubChem CID | 5280965 |
分子量 | 924.08 |
Beilstein号 | 78342 |
溶解性 | Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF |
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敏感性 | 对光和湿度敏感 |
熔点 | >170°C |
分子量 | 924.100 g/mol |
XLogP3 | 0.000 |
氢键供体数Hydrogen Bond Donor Count | 12 |
氢键受体数Hydrogen Bond Acceptor Count | 18 |
可旋转键计数Rotatable Bond Count | 3 |
精确质量Exact Mass | 923.488 Da |
单同位素质量Monoisotopic Mass | 923.488 Da |
拓扑极表面积Topological Polar Surface Area | 320.000 Ų |
重原子数Heavy Atom Count | 65 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 1670.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 19 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 7 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 7 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS07 |
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信号词 | Warning |
危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
个人防护装备 | Eyeshields,Gloves,half-mask respirator (EU),half-mask respirator (US),multi-purpose combination respirator cartridge (US) |
Appearance(A657418) | Yellow to Orange powder |
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Assay(on dried basis) | ≥ 750(μg/mg) |
Loss on drying | 0-5(%) |
Bacterial endotoxins | 0-5(EU/mg) |
Total Aerobic Count | 0-100(cfu/g) |
Solubility(50.00mg/ml in DMF:5MHCl=15:1,Clear to Slightly Hazy) | pass |
Infrared spectrum | Conforms to Structure |
1. Ting Fang, Juan Xiong, Li Wang, Zhe Feng, Sijin Hang, Jinhua Yu, Wanqian Li, Yanru Feng, Hui Lu, Yuanying Jiang. (2023) Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity. Antibiotics-Basel, 12 (12): (1675). [PMID:38136708] [10.3390/antibiotics12121675] |
2. Haifeng Lu, Qi Lu, Hongwu Sun, Zhongkun Wang, Xiang Shi, Yuling Ding, Xiang Ran, Jing Pei, Yubo Pan, Qunlin Zhang. (2023) ROS-Responsive Fluorescent Sensor Array for Precise Diagnosis of Cancer via pH-Controlled Multicolor Gold Nanoclusters. ACS Applied Materials & Interfaces, 15 (32): (38381–38390). [PMID:37531495] [10.1021/acsami.3c09320] |
3. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (12): (4863–4875). [PMID:36919252] [10.1021/acs.jafc.2c08866] |
4. Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang. (2022) A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols. mBio, 14 (1): [PMID:36475771] [10.1128/mbio.02639-22] |
5. Guo Penghao, Chen Jianlong, Tan Yiwei, Xia Li, Zhang Weizheng, Li Xiaojie, Jiang Yujie, Li Ruiying, Chen Chunmei, Liao Kang, Peng Yaqin. (2022) Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China. Frontiers in Microbiology, 13 [PMID:36386677] [10.3389/fmicb.2022.992582] |
6. Xinhua Liu, Youteng Qin, Liyun Dong, Ziyi Han, Tianning Liu, Ying Tang, Yun Yu, Jingjie Ye, Juan Tao, Xuan Zeng, Jun Feng, Xian-Zheng Zhang. (2023) Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis. Bioactive Materials, 21 (253). [PMID:36157249] [10.1016/j.bioactmat.2022.08.019] |
7. Zhongjia Yu, Xiang-Fang Yu, Goher Kerem, Pei-Gen Ren. (2022) Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice. Frontiers in Endocrinology, 13 (795371). [PMID:36017311] [10.3389/fendo.2022.795371] |
8. Xin Yang, Zejun Pei, Renjing Hu, Zhehao Zhang, Zaixiang Lou, Xin Sun. (2021) Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant Candida albicans and Its Biofilms. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44 (3): (305-315). [PMID:33441497] [10.1248/bpb.b20-00246] |
9. Xiaowen He, Lantong Zhang, Jinping Chen, Jinlei Sui, Guohui Yi, Jinyan Wu, Yinzheng Ma. (2019) Correlation between Chemical Composition and Antifungal Activity of Clausena lansium Essential Oil against Candida spp.. MOLECULES, 24 (7): (1394). [PMID:30970599] [10.3390/molecules24071394] |
10. Chen Xing, Chunqing Qin, Xueqing Li, Fuming Zhang, Robert J. Linhardt, Peilong Sun, Anqiang Zhang. (2019) Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot. LWT-FOOD SCIENCE AND TECHNOLOGY, 104 (38). [10.1016/j.lwt.2019.01.020] |
11. Lu Wang, Yanan Wu, Tao Huang, Kan Shi, Zhenqiang Wu. (2017) Chemical Compositions, Antioxidant and Antimicrobial Activities of Essential Oils of Psidium guajava L. Leaves from Different Geographic Regions in China. CHEMISTRY & BIODIVERSITY, 14 (9): (e1700114). [PMID:28618209] [10.1002/cbdv.201700114] |
12. Wang Aoke, Ahmad Aftab, Ullah Sadeeq, Cheng Li, Ke Lin, Yuan Qipeng. (2017) A Cheap and Convenient Method of Liposome Preparation Using Glass Beads as a Source of Shear Force. AAPS PHARMSCITECH, 18 (8): (3227-3235). [PMID:28560505] [10.1208/s12249-017-0812-3] |
13. Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou, Xin-Hang Jiang, Xu-Ming Mao, Shui-Ping Liu, Wen-Jun Guan, Yong-Quan Li. (2017) Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10. MOLECULAR MICROBIOLOGY, 103 (4): (713-728). [PMID:27874224] [10.1111/mmi.13583] |
14. Gao Mei-yue, Qi Huan, Li Jian-song, Zhang Hui, Zhang Ji, Wang Ji-dong, Xiang Wen-sheng. (2016) A new polysubstituted cyclopentene derivative from Streptomyces sp. HS-NF-1046. JOURNAL OF ANTIBIOTICS, 70 (2): (216-218). [PMID:27599764] [10.1038/ja.2016.111] |
1. Ting Fang, Juan Xiong, Li Wang, Zhe Feng, Sijin Hang, Jinhua Yu, Wanqian Li, Yanru Feng, Hui Lu, Yuanying Jiang. (2023) Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity. Antibiotics-Basel, 12 (12): (1675). [PMID:38136708] [10.3390/antibiotics12121675] |
2. Haifeng Lu, Qi Lu, Hongwu Sun, Zhongkun Wang, Xiang Shi, Yuling Ding, Xiang Ran, Jing Pei, Yubo Pan, Qunlin Zhang. (2023) ROS-Responsive Fluorescent Sensor Array for Precise Diagnosis of Cancer via pH-Controlled Multicolor Gold Nanoclusters. ACS Applied Materials & Interfaces, 15 (32): (38381–38390). [PMID:37531495] [10.1021/acsami.3c09320] |
3. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (12): (4863–4875). [PMID:36919252] [10.1021/acs.jafc.2c08866] |
4. Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang. (2022) A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols. mBio, 14 (1): [PMID:36475771] [10.1128/mbio.02639-22] |
5. Guo Penghao, Chen Jianlong, Tan Yiwei, Xia Li, Zhang Weizheng, Li Xiaojie, Jiang Yujie, Li Ruiying, Chen Chunmei, Liao Kang, Peng Yaqin. (2022) Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China. Frontiers in Microbiology, 13 [PMID:36386677] [10.3389/fmicb.2022.992582] |
6. Xinhua Liu, Youteng Qin, Liyun Dong, Ziyi Han, Tianning Liu, Ying Tang, Yun Yu, Jingjie Ye, Juan Tao, Xuan Zeng, Jun Feng, Xian-Zheng Zhang. (2023) Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis. Bioactive Materials, 21 (253). [PMID:36157249] [10.1016/j.bioactmat.2022.08.019] |
7. Zhongjia Yu, Xiang-Fang Yu, Goher Kerem, Pei-Gen Ren. (2022) Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice. Frontiers in Endocrinology, 13 (795371). [PMID:36017311] [10.3389/fendo.2022.795371] |
8. Xin Yang, Zejun Pei, Renjing Hu, Zhehao Zhang, Zaixiang Lou, Xin Sun. (2021) Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant Candida albicans and Its Biofilms. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44 (3): (305-315). [PMID:33441497] [10.1248/bpb.b20-00246] |
9. Xiaowen He, Lantong Zhang, Jinping Chen, Jinlei Sui, Guohui Yi, Jinyan Wu, Yinzheng Ma. (2019) Correlation between Chemical Composition and Antifungal Activity of Clausena lansium Essential Oil against Candida spp.. MOLECULES, 24 (7): (1394). [PMID:30970599] [10.3390/molecules24071394] |
10. Chen Xing, Chunqing Qin, Xueqing Li, Fuming Zhang, Robert J. Linhardt, Peilong Sun, Anqiang Zhang. (2019) Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot. LWT-FOOD SCIENCE AND TECHNOLOGY, 104 (38). [10.1016/j.lwt.2019.01.020] |
11. Lu Wang, Yanan Wu, Tao Huang, Kan Shi, Zhenqiang Wu. (2017) Chemical Compositions, Antioxidant and Antimicrobial Activities of Essential Oils of Psidium guajava L. Leaves from Different Geographic Regions in China. CHEMISTRY & BIODIVERSITY, 14 (9): (e1700114). [PMID:28618209] [10.1002/cbdv.201700114] |
12. Wang Aoke, Ahmad Aftab, Ullah Sadeeq, Cheng Li, Ke Lin, Yuan Qipeng. (2017) A Cheap and Convenient Method of Liposome Preparation Using Glass Beads as a Source of Shear Force. AAPS PHARMSCITECH, 18 (8): (3227-3235). [PMID:28560505] [10.1208/s12249-017-0812-3] |
13. Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou, Xin-Hang Jiang, Xu-Ming Mao, Shui-Ping Liu, Wen-Jun Guan, Yong-Quan Li. (2017) Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10. MOLECULAR MICROBIOLOGY, 103 (4): (713-728). [PMID:27874224] [10.1111/mmi.13583] |
14. Gao Mei-yue, Qi Huan, Li Jian-song, Zhang Hui, Zhang Ji, Wang Ji-dong, Xiang Wen-sheng. (2016) A new polysubstituted cyclopentene derivative from Streptomyces sp. HS-NF-1046. JOURNAL OF ANTIBIOTICS, 70 (2): (216-218). [PMID:27599764] [10.1038/ja.2016.111] |