| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A424182-1ml |
1ml |
现货  |
|
| 别名 | 芦荟泻素 |
|---|---|
| 英文别名 | 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- | Aloeemodin | Aloe-emodin | Aloe-emodin, analytical standard | Q-100526 | MLS000697563 | s2259 | CCG-208456 | SR-01000765772-3 | 3-(Hydroxymethyl)chrysazin | 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-hydroxymethyl-anthrac |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Aloe-emodin |
| 生化机理 | 泻药/泻药化合物；通过释放内源性乙酰胆碱增加肠道平滑肌的收缩。抗肿瘤活性与活性氧（ROS）的产生增加有关，ROS 的产生反过来又会降低线粒体跨膜电位，从而诱发通透性转换，引发一系列事件，最终导致细胞凋亡。基因毒性和诱变性似乎是由于芦荟大黄素抑制了拓扑异构酶 II 的活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
易溶于热乙醇，在苯及乙醚中呈黄色，在氨水和硫酸中呈绯红色，属蒽醌类化合物，在酸性溶液中被还原则生成蒽酚及其互变异构体的蒽酮。 |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 207-571-7 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione |
| INCHI | InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 |
| InChi Key | YDQWDHRMZQUTBA-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
| Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
| WGK Germany | 3 |
| RTECS | CB6712200 |
| PubChem CID | 10207 |
| 分子量 | 270.24 |
| Beilstein号 | 2059062 |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 223-224°C |
| 分子量 | 270.240 g/mol |
| XLogP3 | 1.800 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 270.053 Da |
| 单同位素质量Monoisotopic Mass | 270.053 Da |
| 拓扑极表面积Topological Polar Surface Area | 94.800 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 420.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | CB6712200 |
| Merck Index | 306 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Orange Liquid) | Pass |
| Record the entire process by video | Conform |
| 1. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
| 2. Huijie Gao, Yan Ren, Chao Liu. (2022) Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis. Evidence-based Complementary and Alternative Medicine, 2022 (9697887). [PMID:35978995] [10.1155/2022/9697887] |
| 3. Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang, Yuanyuan Lu. (2022) 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. RESEARCH IN MICROBIOLOGY, 173 (103955). [PMID:35550403] [10.1016/j.resmic.2022.103955] |
| 4. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] [10.3389/fphar.2022.842720] |
| 5. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] [10.3390/foods11030386] |
| 6. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [10.1016/j.microc.2019.104245] |
| 7. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [10.1016/j.snb.2019.04.129] |
| 8. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [10.1016/j.cej.2018.12.014] |
| 9. Wang Qianqian, Xu Yixiang, Xu Jiaqi, Wang Xudong, Shen Chen, Zhang Yan, Liu Xiufeng, Yu Boyang, Zhang Jian. (2017) Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. BIOTECHNOLOGY LETTERS, 39 (8): (1229-1235). [PMID:28484911] [10.1007/s10529-017-2352-z] |
| 10. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [10.1002/app.44874] |
| 11. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] [10.1002/jssc.201401341] |
| 12. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
| 1. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
| 2. Huijie Gao, Yan Ren, Chao Liu. (2022) Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis. Evidence-based Complementary and Alternative Medicine, 2022 (9697887). [PMID:35978995] [10.1155/2022/9697887] |
| 3. Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang, Yuanyuan Lu. (2022) 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. RESEARCH IN MICROBIOLOGY, 173 (103955). [PMID:35550403] [10.1016/j.resmic.2022.103955] |
| 4. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] [10.3389/fphar.2022.842720] |
| 5. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] [10.3390/foods11030386] |
| 6. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [10.1016/j.microc.2019.104245] |
| 7. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [10.1016/j.snb.2019.04.129] |
| 8. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [10.1016/j.cej.2018.12.014] |
| 9. Wang Qianqian, Xu Yixiang, Xu Jiaqi, Wang Xudong, Shen Chen, Zhang Yan, Liu Xiufeng, Yu Boyang, Zhang Jian. (2017) Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. BIOTECHNOLOGY LETTERS, 39 (8): (1229-1235). [PMID:28484911] [10.1007/s10529-017-2352-z] |
| 10. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [10.1002/app.44874] |
| 11. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] [10.1002/jssc.201401341] |
| 12. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
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