计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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A119533-5mg |
5mg |
现货 ![]() |
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A119533-25mg |
25mg |
现货 ![]() |
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A119533-100mg |
100mg |
现货 ![]() |
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A119533-500mg |
500mg |
现货 ![]() |
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A119533-1g |
1g |
现货 ![]() |
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A119533-5g |
5g |
现货 ![]() |
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别名 | 5-氮杂-2'-脱氧胞苷 | 5-氮杂-1-(2-脱氧-β-D-呋喃核糖基)胞嘧啶 | 地西他滨 2'-脱氧-5-氮杂胞苷 | 4-氨基-1-(2-脱氧-β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)- 酮 |
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英文别名 | 2-deoxyazacytidine | 5-Aza-2'-deoxycytidine, >=97% | 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one | 2'-desoxy-5-azacytidine | 2-Desoxy-5-azacytidine | E-7373 | MLS006010136 | NSC127716 | NSC-127716 | DECITABINE (MART.) | DECITABIN |
规格或纯度 | Moligand™, ≥98% |
英文名称 | 5-Aza-2′-deoxycytidine |
生化机理 | 5′-Azadeoxycytidine 可导致 DNA 去甲基化或半去甲基化。DNA 去甲基化可通过 "打开 "染色质结构来调节基因表达,染色质结构的 "打开 "可检测到核酸酶敏感性的提高。这种染色质结构的重塑可使转录因子结合到启动子区域、转录复合物的组装以及基因的表达。DNA 甲基转移酶 1 (DNMT1) 的强效抑制剂(IC 50 = 0.2 μM)。与 DNA 结合,抑制 DNMT1 的活性,诱导 DNA 低甲基化。干扰蛋白质合成。体外具有抗代谢和抗癌活性 .在体内具有活性 . |
储存温度 | 2-8°C储存,充氩 |
运输条件 | 冰袋运输 |
作用类型 | 抑制剂 |
作用机制 | DNA(胞嘧啶-5)-甲基转移酶 1 抑制剂 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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PubChem SID | 488189867 |
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EC号 | 219-089-4 |
分子类型 | 小分子 |
IUPAC Name | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
INCHI | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 |
InChi Key | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
Canonical SMILES | C1C(C(OC1N2C=NC(=NC2=O)N)CO)O |
Isomeric SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O |
WGK Germany | 3 |
RTECS | XZ3012000 |
PubChem CID | 451668 |
分子量 | 228.21 |
Beilstein号 | 617982 |
敏感性 | 对光线敏感;对热敏感 |
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熔点 | 191 °C(dec.) |
分子量 | 228.210 g/mol |
XLogP3 | -1.200 |
氢键供体数Hydrogen Bond Donor Count | 3 |
氢键受体数Hydrogen Bond Acceptor Count | 4 |
可旋转键计数Rotatable Bond Count | 2 |
精确质量Exact Mass | 228.086 Da |
单同位素质量Monoisotopic Mass | 228.086 Da |
拓扑极表面积Topological Polar Surface Area | 121.000 Ų |
重原子数Heavy Atom Count | 16 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 356.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS08, GHS07 |
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信号词 | Danger |
危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H302: 吞食有害 H360: 可能损害生育力或未出生的孩子 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P281: 根据需要使用个人防护设备。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P330: 漱口 P203: 使用前,获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽:请寻求医疗帮助。 P318: 如果暴露或担心,请就医。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
WGK Germany | 3 |
RTECS | XZ3012000 |
Merck Index | 2853 |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Purity(HPLC) | 98-100(%) |
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Appearance(A119533) | White to Off-White Powder |
Infrared spectrum | Conforms to Structure |
Proton NMR spectrum | Conforms to Structure |
Solubility,Colorless Clear 50 mg/ml, HOAc and H2O (1:1) | pass |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
批号(Lot Number) | 证书类型 | 日期 | 货号 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 23-01-07 | A119533 |
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分析证书 | 22-07-19 | A119533 |
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分析证书 | 22-05-18 | A119533 |
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分析证书 | 22-02-19 | A119533 |
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分析证书 | 21-10-26 | A119533 |
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分析证书 | 21-04-17 | A119533 |
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分析证书 | 21-04-17 | A119533 |
¥439.90
1. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du. (2023) Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy. Small, (15): (2306905). [PMID:37880861] [10.1002/smll.202306905] |
2. Shuoyi Zhang, Ming Zhong, Hongbo Zhu, Qinghua You, Hao Yuan, Yongping Li. (2023) Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway. Cancer Genetics, [PMID:37729778] [10.1016/j.cancergen.2023.09.001] |
3. Weichu Zhu, Jian Xu, Xianxian Yao, Shuting Mai, Dan Shu, Wuli Yang. (2023) Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy. Biomaterials Science, [PMID:37470092] [10.1039/D3BM00813D] |
4. An Yaqian, Yu Zhiqi, Liu Di, Han Lirong, Zhang Xian, Xin Xuelian, Li Cuiping. (2023) HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (12): (2271-2280). [PMID:36961574] [10.1007/s00216-023-04647-1] |
5. Fan Du, Ting Jin, Li Wang. (2023) Mechanism of Action of Decitabine in the Treatment of Acute Myeloid Leukemia by Regulating LINC00599. Analytical Cellular Pathology, 2023 (2951519). [PMID:36874552] [10.1155/2023/2951519] |
6. Hailin Yu, Huili Zhang, Xin Wei, Yong Chen, Bo Yu, Yingjun Wang, Hongsheng Liu. (2023) Preparation of a cationic block copolymer composite coagulant TP(AM-DAC-PPFS) and its coagulation performance for treating oilfield sewage. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 171 (341). [10.1016/j.psep.2022.12.060] |
7. Tong Gao, Xiao Sang, Xinyan Huang, Panpan Gu, Jie Liu, Yongjun Liu, Na Zhang. (2022) Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer. Acta Pharmaceutica Sinica B, [PMID:37799382] [10.1016/j.apsb.2022.11.018] |
8. Shi Guang, Feng Juan, Jian Ling-Yan, Fan Xin-Yu. (2022) DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury. Neural Regeneration Research, 18 (4): (863). [PMID:36204855] [10.4103/1673-5374.353494] |
9. Duan Houyu, Ding Xiang, Luo Hesheng. (2022) KISS-1, Mediated by Promoter Methylation, Suppresses Esophageal Squamous Cell Carcinoma Metastasis via MMP2/9/MAPK Axis. DIGESTIVE DISEASES AND SCIENCES, 67 (10): (4780-4796). [PMID:34993679] [10.1007/s10620-021-07335-1] |
10. Peng Yi, Xiongfeng Xu, Jiawei Yao, Bo Qiu. (2021) Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis. Experimental and Therapeutic Medicine, 22 (1): (1-8). [PMID:34007328] [10.3892/etm.2021.10151] |
11. Yafei Wang, Huimin Liu, Jianmin Wu, Yunjian Liao, Daifeng Lu, Feng Dong, Hongxi Li, Zhitao Zhang, Yongyun Lian. (2020) 5-Aza-2-deoxycytidine inhibits osteolysis induced by titanium particles by regulating RANKL/OPG ratio. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 529 (629). [PMID:32736684] [10.1016/j.bbrc.2020.05.192] |
12. Mengmeng Shu, Shijun Long, Yiwan Huang, Dapeng Li, Haiyan Li, Xuefeng Li. (2019) High strength and antibacterial polyelectrolyte complex CS/HS hydrogel films for wound healing. Soft Matter, 15 (38): (7686-7694). [PMID:31498364] [10.1039/C9SM01380F] |
13. Li Zhang, Xiaofen Xiao, Yuzhi Xu, Danping Chen, Jun Chen, Yingjun Ma, Zong Dai, Xiaoyong Zou. (2018) Electrochemical assay for continuous monitoring of dynamic DNA methylation process. BIOSENSORS & BIOELECTRONICS, 100 (184). [PMID:28889069] [10.1016/j.bios.2017.08.013] |
14. Qing Wang, Pu Wang, Hong Zhou, Yan Hu, Chengshen Xie, Fei Gao, Ningjie Ma, Haoli Hou, Hao Zhang, Lijia Li. (2017) 5-Azacytidine specifically inhibits the NIH-3T3 PCD process induced by TNF-alpha and cycloheximide via affecting BCL-XL. JOURNAL OF CELLULAR BIOCHEMISTRY, 119 (2): (1501-1510). [PMID:28777484] [10.1002/jcb.26310] |
15. Jing Yin, Feilong Zhu, Weiyu Hao, Qi Xu, Jin Chang, Huili Wang, Baoyuan Guo. (2017) Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation. FOOD AND CHEMICAL TOXICOLOGY, 109 (735). [PMID:28456568] [10.1016/j.fct.2017.04.038] |
16. Yongjun Sun, Chengyu Zhu, Wenquan Sun, Yanhua Xu, Xuefeng Xiao, Huaili Zheng, Huifang Wu, Cuiyun Liu. (2017) Plasma-initiated polymerization of chitosan-based CS-g-P(AM-DMDAAC) flocculant for the enhanced flocculation of low-algal-turbidity water. CARBOHYDRATE POLYMERS, 164 (222). [PMID:28325320] [10.1016/j.carbpol.2017.02.010] |
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4. Evans MR et al.. (2019) Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.. J Virol, 93 (4): [PMID:30518656] |
5. Zeng X et al.. (2018) Secreted Frizzled Related Protein 2 Modulates Epithelial-Mesenchymal Transition and Stemness via Wnt/ß-Catenin Signaling in Choriocarcinoma.. Cell Physiol Biochem, 50 (5): (1815-1831). [PMID:30396168] |
6. Mulati K et al.. (2019) VISTA expressed in tumour cells regulates T cell function.. Br J Cancer, 120 (115-127). [PMID:30382166] |
7. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du. (2023) Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy. Small, (15): (2306905). [PMID:37880861] [10.1002/smll.202306905] |
8. Shuoyi Zhang, Ming Zhong, Hongbo Zhu, Qinghua You, Hao Yuan, Yongping Li. (2023) Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway. Cancer Genetics, [PMID:37729778] [10.1016/j.cancergen.2023.09.001] |
9. Weichu Zhu, Jian Xu, Xianxian Yao, Shuting Mai, Dan Shu, Wuli Yang. (2023) Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy. Biomaterials Science, [PMID:37470092] [10.1039/D3BM00813D] |
10. An Yaqian, Yu Zhiqi, Liu Di, Han Lirong, Zhang Xian, Xin Xuelian, Li Cuiping. (2023) HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (12): (2271-2280). [PMID:36961574] [10.1007/s00216-023-04647-1] |
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