基本描述

别名	盐酸左氧氟沙星盐酸盐 \| 1-金刚烷乙胺盐酸盐 \| α-甲基-1-金刚烷甲胺盐酸盐 \| 盐酸金刚乙胺
英文别名	1-(1-Adamantyl)ethylamine hydrochloride, 99% \| 1-(ADAMANTAN-1-YL)ETHAN-1-AMINE HYDROCHLORIDE \| MLS002548886 \| RIMANTADINE HYDROCHLORIDE (MART.) \| Rimantadine hydrochloride [USAN:USP] \| Rimantadine, HCl \| 1-(1-Aminoethyl)adamantane HCl \| Algirem \| DTXCID30
规格或纯度	≥99%
英文名称	1-(1-Adamantyl)ethylamine hydrochloride
生化机理	M2质子通道抑制剂。在体内抑制甲型流感病毒。与盐酸金刚烷胺相比，具有更高的血脑屏障通透性。口服具有活性。
运输条件	常规运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Product Application: 1-(1-Adamantyl)ethylamine hydrochloride is indicated for the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults (17 years and older).

AI解读

名称和识别符

PubChem SID	488182078
IUPAC Name	1-(1-adamantyl)ethanamine;hydrochloride
INCHI	InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
InChi Key	OZBDFBJXRJWNAV-UHFFFAOYSA-N
Canonical SMILES	CC(C12CC3CC(C1)CC(C3)C2)N.Cl
Isomeric SMILES	CC(C12CC3CC(C1)CC(C3)C2)N.Cl
WGK Germany	3
RTECS	AU4717000
分子量	215.77
Reaxy-Rn	3623918
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3623918&ln=

化学和物理性质

溶解性	Freely soluble in water.
熔点	375°C
分子量	215.760 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	215.144 Da
单同位素质量Monoisotopic Mass	215.144 Da
拓扑极表面积Topological Polar Surface Area	26.000 Å²
重原子数Heavy Atom Count	14
形式电荷Formal Charge	0
复杂度Complexity	180.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	1
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS07
信号词	Warning
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	AU4717000
Reaxy-Rn	3623918
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3623918&ln=
Merck Index	8224
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

SDS英文版

技术规格说明书

Purity(Titration by AgNO3)	98.5-101.5（%）
Appearance（A118559)	White Powder or Crystals
Infrared spectrum	Conforms to Structure
Solubility in hot H2O	almost transparency

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到12个结果

批号(Lot Number)	证书类型	日期	货号
G2113060	分析证书	25-04-08	A118559
E1921074	分析证书	23-03-09	A118559
B2304074	分析证书	22-12-08	A118559
B2304092	分析证书	22-12-08	A118559
B2304093	分析证书	22-12-08	A118559
B2304094	分析证书	22-12-08	A118559
B2304095	分析证书	22-12-08	A118559
B2304097	分析证书	22-12-08	A118559
B2304098	分析证书	22-12-08	A118559
B2304099	分析证书	22-12-08	A118559
B2304116	分析证书	22-12-08	A118559
E2312091	分析证书	22-12-08	A118559

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参考文献

1. Segovia M et al.. (2019) Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.. Cancer Cell, 35 (5): (767-781.e6). [PMID:31085177]
2. G G U Rohde. (2011-08-03) [Influenza : clinical symptoms, diagnostics and therapy].. Der Internist, 52 ((9)): (1047-1052). [PMID:21809066]
3. Belen Puente,Esther Hernandez,Susana Perez,Luis Pablo,Esther Prieto,Maria Angeles Garcia,Miguel Angel Bregante. (2011-11-15) Determination of memantine in plasma and vitreous humour by HPLC with precolumn derivatization and fluorescence detection.. Journal of chromatographic science, 49 ((10)): (745-752). [PMID:22080801]
4. Linh Tran,Sy Bing Choi,Belal O Al-Najjar,Muhammad Yusuf,Habibah A Wahab,Ly Le. (2011-12-14) Discovery of potential M2 channel inhibitors based on the amantadine scaffold via virtual screening and pharmacophore modeling.. Molecules (Basel, Switzerland), 16 ((12)): (10227-10255). [PMID:22158591]
5. Sander A A Kooijmans,Danielle Senyschyn,Muguntha M Mezhiselvam,Julia Morizzi,Susan A Charman,Babette Weksler,Ignacio-Andres Romero,Pierre-Olivier Couraud,Joseph A Nicolazzo. (2012-02-23) The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine.. Molecular pharmaceutics, 9 ((4)): (883-893). [PMID:22352408]
6. Jonathan Hsu,Nancy Santesso,Reem Mustafa,Jan Brozek,Yao Long Chen,Jessica P Hopkins,Adrienne Cheung,Gayane Hovhannisyan,Liudmila Ivanova,Signe A Flottorp,Ingvil Saeterdal,Arthur D Wong,Jinhui Tian,Timothy M Uyeki,Elie A Akl,Pablo Alonso-Coello,Fiona Smaill,Holger J Schünemann. (2012-03-01) Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies.. Annals of internal medicine, 156 ((7)): (512-524). [PMID:22371849]
7. Tijana Ivanovic,Rutger Rozendaal,Daniel L Floyd,Milos Popovic,Antoine M van Oijen,Stephen C Harrison. (2012-03-14) Kinetics of proton transport into influenza virions by the viral M2 channel.. PloS one, 7 ((3)): (e31566-e31566). [PMID:22412838]
8. Loren B Andreas,Matthew T Eddy,James J Chou,Robert G Griffin. (2012-04-07) Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A.. Journal of the American Chemical Society, 134 ((17)): (7215-7218). [PMID:22480220]
9. Lora Simeonova,Galina Gegova,Angel S Galabov. (2012-05-24) Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice.. Antiviral research, 95 ((2)): (172-181). [PMID:22617756]
10. V A Shibnev,T M Garaev,M P Finogenova,E S Shevchenko,E I Burtseva. (2012-07-21) New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine.. Bulletin of experimental biology and medicine, 153 ((2)): (233-235). [PMID:22816091]
11. Yuxin Zhang,Hujun Shen,Mingbo Zhang,Guohui Li. (2013-01-05) Exploring the proton conductance and drug resistance of BM2 channel through molecular dynamics simulations and free energy calculations at different pH conditions.. The journal of physical chemistry. B, 117 ((4)): (982-988). [PMID:23286443]
12. Bo OuYang,Shiqi Xie,Marcelo J Berardi,Xinhao Zhao,Jyoti Dev,Wenjing Yu,Bing Sun,James J Chou. (2013-06-07) Unusual architecture of the p7 channel from hepatitis C virus.. Nature, 498 ((7455)): (521-525). [PMID:23739335]
13. George Atiee,Kenneth Lasseter,Sharon Baughman,Amy McCullough,Phil Collis,Alan Hollister,Jaime Hernandez. (2011-10-01) Absence of pharmacokinetic interaction between intravenous peramivir and oral oseltamivir or rimantadine in humans.. Journal of clinical pharmacology, 52 ((9)): (1410-1419). [PMID:21960669]
14. Saumil Doshi,Laurie Kamimoto,Lyn Finelli,Alejandro Perez,Arthur Reingold,Ken Gershman,Kimberly Yousey-Hindes,Kathryn Arnold,Patricia Ryan,Ruth Lynfield,Craig Morin,Joan Baumbach,Emily B Hancock,Nancy M Bennett,Shelley Zansky,Ann Thomas,William Schaffner,Alicia M Fry. (2011-10-21) Description of antiviral treatment among adults hospitalized with influenza before and during the 2009 pandemic: United States, 2005-2009.. The Journal of infectious diseases, 204 ((12)): (1848-1856). [PMID:22013219]
15. Georgina Cirrincione-Dall,Barbara J Brennan,Rosa M Ballester-Sanchis,Mercidita T Navarro,Brian E Davies. (2011-11-01) Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: an open-label, multiple-dose, randomized, crossover study.. Journal of clinical pharmacology, 52 ((8)): (1255-1264). [PMID:22039289]
16. Rafal M Pielak,Kirill Oxenoid,James J Chou. (2011-11-15) Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.. Structure (London, England : 1993), 19 ((11)): (1655-1663). [PMID:22078564]
17. Mona Alqazzaz,Andrew J Thompson,Kerry L Price,Hans-Georg Breitinger,Sarah C R Lummis. (2012-01-03) Cys-loop receptor channel blockers also block GLIC.. Biophysical journal, 101 ((12)): (2912-2918). [PMID:22208189]
18. Suelen F Sucena,Raphael E F Paiva,Camilla Abbehausen,Ives B Mattos,Marcelo Lancellotti,André L B Formiga,Pedro P Corbi. (2012-01-20) Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 89 (114-118). [PMID:22257715]
19. Márcia G Alves Galvão,Marilene Augusta Rocha Crispino Santos,Antonio Jl Alves da Cunha. (2012-01-20) Amantadine and rimantadine for influenza A in children and the elderly.. The Cochrane database of systematic reviews, 1 (CD002745-CD002745). [PMID:22258950]
20. Guang-Quan Wang,Yan-Fang Qin,Li-Ming Du,Jun-Fei Li,Xu Jing,Yin-Xia Chang,Hao Wu. (2012-09-11) Determination of amantadine and rimantadine using a sensitive fluorescent probe.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 98 (275-281). [PMID:22959366]
21. Loren B Andreas,Alexander B Barnes,Björn Corzilius,James J Chou,Eric A Miller,Marc Caporini,Melanie Rosay,Robert G Griffin. (2013-03-14) Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A.. Biochemistry, 52 ((16)): (2774-2782). [PMID:23480101]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

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体积

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分子量

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稀释计算器

计算配制储备溶液所需的稀释度。

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体积 1 (V1)

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浓度 2 (C2)

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体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

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质量（小瓶）

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
A118559-1g	1g	现货
A118559-5g	5g	现货
A118559-25g	25g	现货
A118559-100g	100g	现货
A118559-500g	500g	现货

1-(1-金刚烷基)乙基胺盐酸盐

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器