基本描述

别名	乙酰谷氨酰胺
英文别名	Ac-Gln-OH \| HMS2230O15 \| A817539 \| acetyl-l-glutamine \| Tox21_113393 \| Aceglutamida [INN-Spanish] \| DB04167 \| HMS3885H06 \| UNII-01J18G9G97 \| A-Acetyl-L-glutamine \| N-Acetylglutamine \| Tox21_110702_1 \| s4512 \| (2S)-2-acetamido-5-azanyl-5-oxidanylidene-pent
规格或纯度	≥99%
英文名称	N-Acetyl-L-Glutamine
应用	一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂（farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。
储存温度	2-8°C储存
运输条件	冰袋运输
产品介绍	易溶于水，能溶于乙醇和乙酸乙酯。一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂（farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。

AI解读

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504757719
EC号	219-647-7
分子类型	小分子
IUPAC Name	(2S)-2-acetamido-5-amino-5-oxopentanoic acid
INCHI	InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1
InChi Key	KSMRODHGGIIXDV-YFKPBYRVSA-N
Canonical SMILES	CC(=O)NC(CCC(=O)N)C(=O)O
Isomeric SMILES	CC(=O)N[C@@H](CCC(=O)N)C(=O)O
WGK Germany	3
PubChem CID	182230
分子量	188.18
Beilstein号	1727471
Reaxy-Rn	1727471

化学和物理性质

密度	1.29
比旋光度	-12 ° (C=3, H2O)
熔点	195-199°C
分子量	188.180 g/mol
XLogP3	-1.400
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	188.08 Da
单同位素质量Monoisotopic Mass	188.08 Da
拓扑极表面积Topological Polar Surface Area	109.000 Å²
重原子数Heavy Atom Count	13
形式电荷Formal Charge	0
复杂度Complexity	227.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

WGK Germany	3
Reaxy-Rn	1727471
Merck Index	25
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

SDS英文版

技术规格说明书

Glutamine	0-0.1（%）
Specific Rotation [a]20/D(c=3 in H2O)	-13--11（°）
Purity(HPLC)	99-100（%）
Appearance（A117200)	white powder
Proton NMR spectrum	Conforms to structure

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到6个结果

批号(Lot Number)	证书类型	日期	货号
G1915199	分析证书	23-05-06	A117200
B2328318	分析证书	23-03-06	A117200
B2225557	分析证书	22-03-03	A117200
B2225560	分析证书	22-03-03	A117200
B2225504	分析证书	22-03-03	A117200
B2328319	分析证书	21-11-29	A117200

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Ningxiang Yu, Zeyi Wu, Yijue Wang, Abel Wend-Soo Zongo, Xiaohua Nie, Yuanchao Lu, Qin Ye, Xianghe Meng. (2024) Formation of adducts during digestion triggered dietary protein for alleviating cytotoxicity of 2-tert-butyl-1,4-benzoquinone. FOOD AND CHEMICAL TOXICOLOGY, 183 (25): (114200). [PMID:38029872] [10.1016/j.fct.2023.114200]

参考文献

1. M C Gouttebel,C Astre,D Briand,B Saint-Aubert,P M Girardot,H Joyeux. (1992-03-01) Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog.. JPEN. Journal of parenteral and enteral nutrition, 16 ((2)): (117-121). [PMID:1556804]
2. K Sugahara,J Zhang,H Kodama. (1994-07-01) Liquid chromatographic-mass spectrometric analysis of N-acetylamino acids in human urine.. Journal of chromatography. B, Biomedical applications, 657 ((1)): (15-21). [PMID:7952062]
3. C Coudray-Lucas,E Lasnier,F Renaud,F Ziegler,P Settembre,L A Cynober,O G Ekindjian. (1999-08-25) Is alpha-ketoisocaproyl-glutamine a suitable glutamine precursor to sustain fibroblast growth?. Clinical nutrition (Edinburgh, Scotland), 18 ((1)): (29-33). [PMID:10459079]
4. M M Bergana,J D Holton,I L Reyzer,M K Snowden,J H Baxter,V L Pound. (2001-04-21) NMR and MS analysis of decomposition compounds produced from N-acetyl-L-glutamine at low pH.. Journal of agricultural and food chemistry, 48 ((12)): (6003-6010). [PMID:11312773]
5. S X Racine,P Le Toumelin,F Adnet,Y Cohen,M Cupa,E Hantz,L Le Moyec. (2004-08-28) N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy.. Nephron. Physiology, 97 ((4)): (p53-p57). [PMID:15331932]
6. Alexandra Arnaud,Maria Ramírez,J H Jeffrey H Baxter,A J Antonio J Angulo. (2004-11-24) Absorption of enterally administered N-acetyl-l-glutamine versus glutamine in pigs.. Clinical nutrition (Edinburgh, Scotland), 23 ((6)): (1303-1312). [PMID:15556252]
7. Satu Pekkala,Ana I Martínez,Belén Barcelona,Igor Yefimenko,Ulrich Finckh,Vicente Rubio,Javier Cervera. (2010-06-26) Understanding carbamoyl-phosphate synthetase I (CPS1) deficiency by using expression studies and structure-based analysis.. Human mutation, 31 ((7)): (801-808). [PMID:20578160]
8. Hannah C Bygd,Lilusi Ma,Kaitlin M Bratlie. (2017-06-21) Physicochemical properties of liposomal modifiers that shift macrophage phenotype.. Materials science & engineering. C, Materials for biological applications, 79 (237-244). [PMID:28629014]
9. Cecilia Roux,Chiara Riganti,Sammy Ferri Borgogno,Roberta Curto,Claudia Curcio,Valeria Catanzaro,Giuseppe Digilio,Sergio Padovan,Maria Paola Puccinelli,Monica Isabello,Silvio Aime,Paola Cappello,Francesco Novelli. (2017-12-10) Endogenous glutamine decrease is associated with pancreatic cancer progression.. Oncotarget, 8 ((56)): (95361-95376). [PMID:29221133]
10. Ninghua Huang,Bing Cao,Elisa Brietzke,Caroline Park,Danielle Cha,Zihang Pan,Judy Zhu,Yaqiong Liu,Qing Xie,Jing Zeng,Roger S McIntyre,Jingyu Wang,Lailai Yan. (2018-12-24) A pilot case-control study on the association between N-acetyl derivatives in serum and first-episode schizophrenia.. Psychiatry research, 272 (36-41). [PMID:30579179]
11. Yukako Komaki,Adam M-A Simpson,Jong Kwon Choe,Margaux M Pinney,Daniel Herschlag,Yi-Hsueh Chuang,William A Mitch. (2019-07-28) Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation.. Free radical biology & medicine, 141 (475-482). [PMID:31349038]
12. Y Chen. (1992-01-01) Clinical research on treating senile dementia by combining acupuncture with acupoint-injection.. Acupuncture & electro-therapeutics research, 17 ((2)): (61-73). [PMID:1353652]
13. D Barrett,N A Breslau,M B Wax,P B Molinoff,R W Downs. (1989-08-11) New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase.. The American journal of physiology, 257 ((2 Pt 1)): (E277-E283). [PMID:2548394]
14. I Magnusson,R Kihlberg,A Alvestrand,J Wernerman,L Ekman,J Wahren. (1989-08-01) Utilization of intravenously administered N-acetyl-L-glutamine in humans.. Metabolism: clinical and experimental, 38 ((8 Suppl 1)): (82-88). [PMID:2569664]
15. G Ollenschläger,A Simmel,E Roth. (1989-08-01) Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures.. Metabolism: clinical and experimental, 38 ((8 Suppl 1)): (40-42). [PMID:2761419]
16. C A Palmerini,G E De Medio,G Porcellati. (1981-07-01) Uptake of doubly-labelled N-acetyl-L-glutamine in rat brain and intestinal mucosa in vivo.. Il Farmaco; edizione pratica, 36 ((7)): (347-355). [PMID:7274416]
17. José M López-Pedrosa,Manuel Manzano,Jeffrey H Baxter,Ricardo Rueda. (2007-01-27) N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs.. Digestive diseases and sciences, 52 ((3)): (650-658). [PMID:17253138]
18. Ningxiang Yu, Zeyi Wu, Yijue Wang, Abel Wend-Soo Zongo, Xiaohua Nie, Yuanchao Lu, Qin Ye, Xianghe Meng. (2024) Formation of adducts during digestion triggered dietary protein for alleviating cytotoxicity of 2-tert-butyl-1,4-benzoquinone. FOOD AND CHEMICAL TOXICOLOGY, 183 (25): (114200). [PMID:38029872] [10.1016/j.fct.2023.114200]

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
A117200-5g	5g	现货
A117200-25g	25g	现货
A117200-100g	100g	现货

N-乙酰-L-谷氨酰胺

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器