基本描述

别名	6-氯鸟嘌呤 \| 6-氯-2-嘌呤胺
英文别名	PD130981 \| BCP27028 \| 6-CHLORO-1H-PURIN-2-AMINE \| 6-Cl-purine (1) \| 2-amino-6-chloro-9h-purine \| 2-Amino-6-chlorpurine \| MFCD00075252 \| UNII-56W89FBX3E \| AKOS005622720 \| UNII-83V03P835E \| 6-chloro-9h-purin-2-ylamine \| Q27139921 \| SR-01000944797 \| 6-Chloro
规格或纯度	≥98%
英文名称	2-Amino-6-chloropurine
运输条件	常规运输
产品介绍	2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method· in the enzymatic synthesis of 2′-deoxyguanosine · in the synthesis of 9-alkyl purines · in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases 2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method

AI解读

关联靶点（人）

DPP4 Tclin 二肽基肽酶4(Dipeptidyl peptidase 4) (1 活性数据)

点击查看靶蛋白信息： DPP4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

XDH Tclin Xanthine dehydrogenase (1038 活性数据)

点击查看靶蛋白信息： XDH

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPRT1 Tchem Hypoxanthine-guanine phosphoribosyltransferase (369 活性数据)

点击查看靶蛋白信息： HPRT1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

DPP4 Dipeptidyl peptidase IV (11 活性数据)

点击查看靶蛋白信息： DPP4

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

J774.A1 (2436 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus anthracis (2936 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488195422
EC号	233-686-7
分子类型	小分子
IUPAC Name	6-chloro-7H-purin-2-amine
INCHI	InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChi Key	RYYIULNRIVUMTQ-UHFFFAOYSA-N
Canonical SMILES	C1=NC2=C(N1)C(=NC(=N2)N)Cl
Isomeric SMILES	C1=NC2=C(N1)C(=NC(=N2)N)Cl
WGK Germany	3
RTECS	UO7502000
PubChem CID	5360349
分子量	169.57
Beilstein号	9626
Reaxy-Rn	610965

化学和物理性质

溶解性	Solubility in 1mol/L NaOH; very faint turbidity.
密度	2.09
熔点	＞300°C
分子量	169.570 g/mol
XLogP3	0.400
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	169.016 Da
单同位素质量Monoisotopic Mass	169.016 Da
拓扑极表面积Topological Polar Surface Area	80.500 Å²
重原子数Heavy Atom Count	11
形式电荷Formal Charge	0
复杂度Complexity	154.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS08, GHS05, GHS07
信号词	Danger
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H412: 对水生生物有害并具有长期持续影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H312: 皮肤接触有害 H332: 吸入有害 H360: 可能损害生育力或未出生的孩子 H350: 可能导致癌症 H362: 可能对母乳喂养的孩子造成伤害
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P281: 根据需要使用个人防护设备。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P263: 避免在怀孕期间/哺乳期间接触。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P318: 如果暴露或担心，请就医。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	UO7502000
Reaxy-Rn	610965
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

SDS英文版

技术规格说明书

Water by Karl Fischer	0-0.5（%）
Purity(Neutralization titration)	97.5-102.5（%）
Purity(HPLC)	98-100（%）
Appearance（A114035)	White to Orange to Green to Yellow to Cream or Pale Yellow powder to crystal
Infrared spectrum	Conforms to Structure
Proton NMR spectrum	Conforms to Structure

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到20个结果

批号(Lot Number)	证书类型	日期	货号
J1731057	分析证书	25-05-12	A114035
J1929197	分析证书	23-08-07	A114035
B2317244	分析证书	23-02-23	A114035
B2317242	分析证书	23-02-23	A114035
E2308214	分析证书	23-02-13	A114035
E2308225	分析证书	23-02-13	A114035
E2308227	分析证书	23-02-13	A114035
E2308228	分析证书	23-02-13	A114035
E2308232	分析证书	23-02-13	A114035
E2308238	分析证书	23-02-13	A114035
E2308239	分析证书	23-02-13	A114035
E2308243	分析证书	23-02-13	A114035
E2308246	分析证书	23-02-13	A114035
E2308253	分析证书	23-02-13	A114035
A2211198	分析证书	21-12-13	A114035
A2211199	分析证书	21-12-13	A114035
A2211215	分析证书	21-12-13	A114035
A2211216	分析证书	21-12-13	A114035
A2211219	分析证书	21-12-13	A114035
B2317230	分析证书	21-12-13	A114035

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang. (2023) Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (23): (8768–8775). [PMID:37232460] [10.1021/acs.est.3c01484]
2. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang. (2020) Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE, 503 (144303). [10.1016/j.apsusc.2019.144303]
3. Haobo Han, Wenqi Chen, Jiebing Yang, Jiayuan Zhang, Quanshun Li, Yan Yang. (2018) 2-Amino-6-chloropurine-modified polyamidoamine-mediated p53 gene transfection to achieve anti-tumor efficacy. NEW JOURNAL OF CHEMISTRY, 42 (16): (13375-13381). [10.1039/C8NJ01870G]
4. Haobo Han, Jiebing Yang, Yudi Wang, Wenqi Chen, Jiawen Chen, Yan Yang, Quanshun Li. (2017) Nucleobase-modified polyamidoamine-mediated miR-23b delivery to inhibit the proliferation and migration of lung cancer. Biomaterials Science, 5 (11): (2268-2275). [PMID:28976503] [10.1039/C7BM00599G]
5. Liu Hongmei, Chang Hong, Lv Jia, Jiang Cong, Li Zhenxi, Wang Fei, Wang Hui, Wang Mingming, Liu Chongyi, Wang Xinyu, Shao Naimin, He Bingwei, Shen Wanwan, Zhang Qiang, Cheng Yiyun. (2016) Screening of efficient siRNA carriers in a library of surface-engineered dendrimers. Scientific Reports, 6 (1): (1-11). [PMID:27121799] [10.1038/srep25069]
6. Hui Wang, Haifeng Wei, Quan Huang, Hongmei Liu, Jingjing Hu, Yiyun Cheng, Jianru Xiao. (2015) Nucleobase-modified dendrimers as nonviral vectors for efficient and low cytotoxic gene delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, 136 (1148). [PMID:26613860] [10.1016/j.colsurfb.2015.11.015]

参考文献

1. J T Kusmierek,B Czochralska,N G Johansson,D Shugar. (1987-11-01) Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.. Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 41 ((10)): (701-707). [PMID:2833054]
2. K Kim,W McComas. (2000-05-02) Chemoselective high-throughput purification mediated by solid-supported reagents: its application to the first 6, 9-disubstituted purine library synthesis.. Combinatorial chemistry & high throughput screening, 3 ((2)): (125-129). [PMID:10788583]
3. Dianne T Keough,Tina Skinner-Adams,Malcolm K Jones,Ai-Lin Ng,Ian M Brereton,Luke W Guddat,John de Jersey. (2006-12-08) Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.. Journal of medicinal chemistry, 49 ((25)): (7479-7486). [PMID:17149876]
4. Jung-Feng Hsieh,Shih-Hsiung Wu,Yu-Liang Yang,Kee-Fong Choong,Shui-Tein Chen. (2007-03-24) The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.. Bioorganic & medicinal chemistry, 15 ((10)): (3450-3456). [PMID:17379526]
5. Zadkiel Alvarez,Kyungae Lee,Ernesto Abel-Santos. (2010-10-06) Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.. Antimicrobial agents and chemotherapy, 54 ((12)): (5329-5336). [PMID:20921305]
6. V Balachandran,K Parimala. (2012-06-19) Tautomeric purine forms of 2-amino-6-chloropurine (N9H10 and N7H10): structures, vibrational assignments, NBO analysis, hyperpolarizability, HOMO-LUMO study using B3 based density functional calculations.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96 (340-351). [PMID:22706099]
7. L L Bennett,D Smithers,L M Rose,D J Adamson,R W Brockman. (1984-01-15) Mode of action of 2-amino-6-chloro-1-deazapurine.. Biochemical pharmacology, 33 ((2)): (261-271). [PMID:6142712]
8. Jan Novák,Igor Linhart,Hana Dvoráková,Vladislav Kubelka. (2003-02-28) Synthesis of 7-hydroxy(phenyl)ethylguanines by alkylation of 2-amino-6-chloropurine with allyl-protected bromohydrins.. Organic letters, 5 ((5)): (637-639). [PMID:12605478]
9. Lak Shin Jeong,Jeong A Lee,Hyung Ryong Moon,Hea Ok Kim,Kang Man Lee,Hyun Joo Lee,Moon Woo Chun. (2007-12-11) Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.. Nucleosides, nucleotides & nucleic acids, 26 ((6-7)): (721-724). [PMID:18066888]
10. Shannen L Cravens,Joseph D Schonhoft,Meng M Rowland,Alyssa A Rodriguez,Breeana G Anderson,James T Stivers. (2015-04-08) Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.. Nucleic acids research, 43 ((8)): (4087-4097). [PMID:25845592]
11. Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang. (2023) Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (23): (8768–8775). [PMID:37232460] [10.1021/acs.est.3c01484]
12. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang. (2020) Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE, 503 (144303). [10.1016/j.apsusc.2019.144303]
13. Haobo Han, Wenqi Chen, Jiebing Yang, Jiayuan Zhang, Quanshun Li, Yan Yang. (2018) 2-Amino-6-chloropurine-modified polyamidoamine-mediated p53 gene transfection to achieve anti-tumor efficacy. NEW JOURNAL OF CHEMISTRY, 42 (16): (13375-13381). [10.1039/C8NJ01870G]
14. Haobo Han, Jiebing Yang, Yudi Wang, Wenqi Chen, Jiawen Chen, Yan Yang, Quanshun Li. (2017) Nucleobase-modified polyamidoamine-mediated miR-23b delivery to inhibit the proliferation and migration of lung cancer. Biomaterials Science, 5 (11): (2268-2275). [PMID:28976503] [10.1039/C7BM00599G]
15. Liu Hongmei, Chang Hong, Lv Jia, Jiang Cong, Li Zhenxi, Wang Fei, Wang Hui, Wang Mingming, Liu Chongyi, Wang Xinyu, Shao Naimin, He Bingwei, Shen Wanwan, Zhang Qiang, Cheng Yiyun. (2016) Screening of efficient siRNA carriers in a library of surface-engineered dendrimers. Scientific Reports, 6 (1): (1-11). [PMID:27121799] [10.1038/srep25069]
16. Hui Wang, Haifeng Wei, Quan Huang, Hongmei Liu, Jingjing Hu, Yiyun Cheng, Jianru Xiao. (2015) Nucleobase-modified dendrimers as nonviral vectors for efficient and low cytotoxic gene delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, 136 (1148). [PMID:26613860] [10.1016/j.colsurfb.2015.11.015]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

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浓度

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分子量

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稀释计算器

计算配制储备溶液所需的稀释度。

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浓度 2 (C2)

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

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质量（小瓶）

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
A114035-1g	1g	现货
A114035-5g	5g	现货
A114035-25g	25g	现货
A114035-100g	100g	现货
A114035-250g	250g	现货

2-氨基-6-氯嘌呤

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器