| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A111285-20mg |
20mg |
现货  |
|
| 别名 | 苦参素 | 苦参碱 N-氧化物 | (41S,7aS,13aR,13bR)-10-氧代十二氢-1H,5H-二吡啶并[2,1-f:3',2',1'-ij][1,6]萘啶4(41H)-氧化物 |
|---|---|
| 英文别名 | Pachycarpidine | BDBM50597716 | Oxymatrine | BBL030371 | MLS001215101 | rel-(41S,7aS,13aR,13bR)-10-Oxohexadecahydrodipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridine 4-oxide | Matrine 1beta-oxide | Ammothamnine | SCHEMBL13394285 | Oxysophoridine | DTXSID409374 |
| 规格或纯度 | 分析标准品 |
| 英文名称 | Ammothamnine |
| 生化机理 | 天然的抗增殖和凋亡化合物。在博来霉素诱导的肺纤维化中抑制iNOS表达和TGF-β/ Smad途径。抗肿瘤，抗病毒和抗心律不齐剂。在体内和体外具有活性。 |
| 储存温度 | 2-8°C储存,避光,充氩 |
| 运输条件 | 冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
从苦参中分离的生物碱。 抗纤维化。保护神经。 Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective. |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | (1R,2R,9S,17S)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one |
| INCHI | InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1 |
| InChi Key | XVPBINOPNYFXID-LHDUFFHYSA-N |
| Canonical SMILES | C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-] |
| Isomeric SMILES | C1C[C@@H]2[C@H]3CCC[N+]4([C@H]3[C@@H](CCC4)CN2C(=O)C1)[O-] |
| 分子量 | 264.36 |
| 密度 | 1.399 |
|---|---|
| 敏感性 | 对光、空气和热敏感 |
| 熔点 | 206℃ |
| 分子量 | 264.360 g/mol |
| XLogP3 | 1.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 264.184 Da |
| 单同位素质量Monoisotopic Mass | 264.184 Da |
| 拓扑极表面积Topological Polar Surface Area | 38.400 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 400.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Purity(HPLC) | 99-100（%） |
|---|---|
| Appearance（A111285) | White to Off-White Powder or Crystals |
| Infrared spectrum | Conforms to Structure |
| Proton NMR spectrum | Conforms to Structure |
| 1. Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. (2023) Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 125 (111144). [PMID:37922569] [10.1016/j.intimp.2023.111144] |
| 2. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] [10.1111/jfd.13818] |
| 3. Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. (2022) Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. HUMAN & EXPERIMENTAL TOXICOLOGY, [PMID:35290143] [10.1177/09603271221078866] |
| 4. Jin Yinshan, Liu Jiannan, Liu Yadong, Liu Yang, Guo Guiying, Yu Shiliang, An Ruihua. (2020) Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression. Frontiers in Pharmacology, 11 (808). [PMID:32581789] [10.3389/fphar.2020.00808] |
| 5. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 6. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
| 1. Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. (2023) Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 125 (111144). [PMID:37922569] [10.1016/j.intimp.2023.111144] |
| 2. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] [10.1111/jfd.13818] |
| 3. Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. (2022) Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. HUMAN & EXPERIMENTAL TOXICOLOGY, [PMID:35290143] [10.1177/09603271221078866] |
| 4. Jin Yinshan, Liu Jiannan, Liu Yadong, Liu Yang, Guo Guiying, Yu Shiliang, An Ruihua. (2020) Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression. Frontiers in Pharmacology, 11 (808). [PMID:32581789] [10.3389/fphar.2020.00808] |
| 5. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 6. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
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