基本描述

别名	黄芪甲甙
英文别名	Astragaloside A \| AKOS025311424 \| AKOS027470287 \| CCG-270470 \| HMS3885E12 \| Astrasieversianin XIV \| s3901 \| (2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethy
规格或纯度	分析标准品, ≥98%
英文名称	Astragaloside IV
生化机理	消炎。
应用	黄芪化学成分的研究
运输条件	常规运输
产品介绍	黄芪化学成分的研究

AI解读

关联靶点（人）

HepG2 (196354 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis B virus (7925 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Duck hepatitis B virus (235 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pulmonary artery (4 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504767538
分子类型	小分子
IUPAC Name	(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
INCHI	InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
InChi Key	QMNWISYXSJWHRY-YLNUDOOFSA-N
Canonical SMILES	CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C
Isomeric SMILES	C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O
WGK Germany	3
PubChem CID	13943297
分子量	784.97

化学和物理性质

密度	1.39
熔点	295-296°C
分子量	785.000 g/mol
XLogP3	1.300
氢键供体数Hydrogen Bond Donor Count	9
氢键受体数Hydrogen Bond Acceptor Count	14
可旋转键计数Rotatable Bond Count	7
精确质量Exact Mass	784.461 Da
单同位素质量Monoisotopic Mass	784.461 Da
拓扑极表面积Topological Polar Surface Area	228.000 Å²
重原子数Heavy Atom Count	55
形式电荷Formal Charge	0
复杂度Complexity	1460.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	21
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

WGK Germany	3
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

SDS英文版

技术规格说明书

Purity(HPLC)	98-100（%）
Melting point	295-296（℃）
Appearance（A111275)	Colorless or White Powder
Mass spectrum	Conforms to standard

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到10个结果

批号(Lot Number)	证书类型	日期	货号
A2329160	分析证书	24-11-20	A111275
A2329165	分析证书	24-11-20	A111275
J2430702	分析证书	24-11-05	A111275
E2217033	分析证书	24-02-05	A111275
E2217036	分析证书	24-02-05	A111275
E2217037	分析证书	24-02-05	A111275
E2217042	分析证书	24-02-05	A111275
L2007265	分析证书	22-09-20	A111275
L2007264	分析证书	22-09-20	A111275
L2007263	分析证书	22-09-20	A111275

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Chan-juan Chai, Yao Sun, Rui-fang Chi, Hui-yu Yang, Bin Yang, Bao Li. (2024) Astragaloside IV alleviates LPS-induced cardiomyocyte hypertrophy and collagen expression associated with CCL2-mediated activation of NF-κB signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 693 (149367). [PMID:38091841] [10.1016/j.bbrc.2023.149367]
2. Xin Zhao, Jinlong Luo, Ying Huang, Lei Mu, Jueying Chen, Zhen Liang, Zhanhai Yin, Dake Chu, Yong Han, Baolin Guo. (2023) Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds. ACS Nano, 17 (21): (22015–22034). [PMID:37862553] [10.1021/acsnano.3c08625]
3. Qing Xu, Dekun Li, Meixu Wan, Yanxin Zhang, Zhi Li, Aichun Ju. (2023) An Online CMC–LC/MS Method for Screening Angiogenesis Promoting Components in Yiqi Fumai Lyophilization Injection (YQFM). Natural Product Communications, [10.1177/1934578X231182209]
4. Tianshu Chu, Qingye Li, Chun Dai, Xiang Li, Xiang Kong, Yangming Fan, Hongyan Yin, Jianjun Ge. (2023) A novel Nanocellulose-Gelatin-AS-IV external stent resists EndMT by activating autophagy to prevent restenosis of grafts. Bioactive Materials, 22 (466). [PMID:36330163] [10.1016/j.bioactmat.2022.10.013]
5. Xiaoyu Zhu, Fangze Tao, Li Zhang, Yajie Yu, Yanchao Xu, Gang Yang, Zhifeng Wei, Yidong Cheng, Xuelai Yin, Xinyuan Zhang, Wu Wei, Anxi Wang. (2022) Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway. Oxidative Medicine and Cellular Longevity, 2022 (5757367). [PMID:35873803] [10.1155/2022/5757367]
6. Xiaowei Wang, Yufen Li, Ji Li, Yaxuan Gu, Lihong Sang, Dongkai Wang. (2021) NIR stimulus-responsive AstragalosideIV-Indocyanin green liposomes for chemo-photothermal therapy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 64 (102257). [10.1016/j.jddst.2020.102257]
7. Dongyu Xie, Ping Zhou, Lin Liu, Wenjing Jiang, Haina Xie, Liang Zhang, Donghao Xie. (2019) Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload. Biomed Research International, 2019 (3103946). [PMID:31428632] [10.1155/2019/3103946]
8. Jiamao Lin, Lijun Fang, Hui Li, Zhenxiang Li, Linmao Lyu, Haiyong Wang, Jun Xiao. (2019) Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress. EUROPEAN JOURNAL OF PHARMACOLOGY, 859 (172490). [PMID:31229536] [10.1016/j.ejphar.2019.172490]
9. Lu Jianrao, Yi Yang, Pan Ronghua, Zhang Chuanfu, Han Haiyan, Chen Jie, Liu Wenrui. (2018) Berberine protects HK-2 cells from hypoxia/reoxygenation induced apoptosis via inhibiting SPHK1 expression. Journal of Natural Medicines, 72 (2): (390-398). [PMID:29260413] [10.1007/s11418-017-1152-z]

参考文献

1. Chan-juan Chai, Yao Sun, Rui-fang Chi, Hui-yu Yang, Bin Yang, Bao Li. (2024) Astragaloside IV alleviates LPS-induced cardiomyocyte hypertrophy and collagen expression associated with CCL2-mediated activation of NF-κB signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 693 (149367). [PMID:38091841] [10.1016/j.bbrc.2023.149367]
2. Xin Zhao, Jinlong Luo, Ying Huang, Lei Mu, Jueying Chen, Zhen Liang, Zhanhai Yin, Dake Chu, Yong Han, Baolin Guo. (2023) Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds. ACS Nano, 17 (21): (22015–22034). [PMID:37862553] [10.1021/acsnano.3c08625]
3. Qing Xu, Dekun Li, Meixu Wan, Yanxin Zhang, Zhi Li, Aichun Ju. (2023) An Online CMC–LC/MS Method for Screening Angiogenesis Promoting Components in Yiqi Fumai Lyophilization Injection (YQFM). Natural Product Communications, [10.1177/1934578X231182209]
4. Tianshu Chu, Qingye Li, Chun Dai, Xiang Li, Xiang Kong, Yangming Fan, Hongyan Yin, Jianjun Ge. (2023) A novel Nanocellulose-Gelatin-AS-IV external stent resists EndMT by activating autophagy to prevent restenosis of grafts. Bioactive Materials, 22 (466). [PMID:36330163] [10.1016/j.bioactmat.2022.10.013]
5. Xiaoyu Zhu, Fangze Tao, Li Zhang, Yajie Yu, Yanchao Xu, Gang Yang, Zhifeng Wei, Yidong Cheng, Xuelai Yin, Xinyuan Zhang, Wu Wei, Anxi Wang. (2022) Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway. Oxidative Medicine and Cellular Longevity, 2022 (5757367). [PMID:35873803] [10.1155/2022/5757367]
6. Xiaowei Wang, Yufen Li, Ji Li, Yaxuan Gu, Lihong Sang, Dongkai Wang. (2021) NIR stimulus-responsive AstragalosideIV-Indocyanin green liposomes for chemo-photothermal therapy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 64 (102257). [10.1016/j.jddst.2020.102257]
7. Dongyu Xie, Ping Zhou, Lin Liu, Wenjing Jiang, Haina Xie, Liang Zhang, Donghao Xie. (2019) Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload. Biomed Research International, 2019 (3103946). [PMID:31428632] [10.1155/2019/3103946]
8. Jiamao Lin, Lijun Fang, Hui Li, Zhenxiang Li, Linmao Lyu, Haiyong Wang, Jun Xiao. (2019) Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress. EUROPEAN JOURNAL OF PHARMACOLOGY, 859 (172490). [PMID:31229536] [10.1016/j.ejphar.2019.172490]
9. Lu Jianrao, Yi Yang, Pan Ronghua, Zhang Chuanfu, Han Haiyan, Chen Jie, Liu Wenrui. (2018) Berberine protects HK-2 cells from hypoxia/reoxygenation induced apoptosis via inhibiting SPHK1 expression. Journal of Natural Medicines, 72 (2): (390-398). [PMID:29260413] [10.1007/s11418-017-1152-z]

溶液计算器

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
A111275-20mg	20mg	现货
A111275-100mg	100mg	现货
A111275-500mg	500mg	现货
A111275-2.5g	2.5g	现货

黄芪甲苷

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器