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牛蒡子苷元

强效的MEK1抑制剂。还抑制IκBα磷酸化
4篇引用文献
  • ≥98%(HPLC)
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A109807-50mg
 50mg 期货 Stock Image
A109807-250mg
 250mg 现货 Stock Image
A109807-1g
 1g 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Anti-infection (2825) Influenza Virus (253) Metabolic Enzyme/Protease (4888) MMP (147) 芳香聚酮化合物 (19) 苯丙素类 (152)
main product photo

基本描述

英文别名 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)- | SCHEMBL381820 | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-oxidanyl-phenyl)methyl]oxolan-2-one | (3R,4R)-4-[(3,4-dimethoxyphenyl)meth
规格或纯度 ≥98%(HPLC)
英文名称 (-)-Arctigenin
生化机理 抗氧化剂，消炎药，抗增殖药和抗病毒药。通过抑制IκBα磷酸化和p65核易位（IC50 = 10 nM）来抑制LPS诱导的iNOS表达。在体外抑制HIV-1复制。还有效抑制MKK1（MEK1）（IC50 = 0.5 nM），并通过与海藻酸酯受体结合提供神经保护作用。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

Arctigenin is a lignan found in the root of Arctium lappa L. It has been used in pharmacologic, as well as cosmetic, research and has demonstrated several antiviral and anticancer effects.

Arctigenin is a lignan found in the root of Arctium lappa L. It has been used in pharmacologic, as well as cosmetic, research and has demonstrated several antiviral and anticancer effects.

AI解读

关联靶点（人）

CYP2C19 Tchem 细胞色素 P450 2C19(Cytochrome P450 2C19) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MAP2K1 Tclin 双特异性丝裂原活化蛋白激酶激酶 1(Dual specificity mitogen-activated protein kinase kinase 1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
DAPK3 Tchem Death-associated protein kinase 3 (2108 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK11 Tchem MAP kinase p38 beta (2785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP2K6 Tchem Dual specificity mitogen-activated protein kinase kinase 6 (1284 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1G1 Tchem Casein kinase I gamma 1 (2496 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK2B Tchem CaM kinase II beta (1626 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK6 Tclin Cyclin-dependent kinase 6 (1724 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHEK2 Tchem Serine/threonine-protein kinase Chk2 (4015 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK4 Tbio CaM kinase IV (2116 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 (1262 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 (4127 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK2D Tchem CaM kinase II delta (2813 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1G2 Tchem Casein kinase I gamma 2 (2539 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK3 Tchem MAP kinase ERK1 (4725 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKACA Tchem cAMP-dependent protein kinase alpha-catalytic subunit (3475 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK2A Tchem CaM kinase II alpha (1938 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPS6KA3 Tchem Ribosomal protein S6 kinase alpha 3 (4284 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK4 Tchem Serine/threonine-protein kinase PLK4 (1882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STK16 Tchem Serine/threonine-protein kinase 16 (910 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STK10 Tchem Serine/threonine-protein kinase 10 (2119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CLK1 Tchem Dual specificty protein kinase CLK1 (2189 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CLK2 Tchem Dual specificity protein kinase CLK2 (3942 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CLK3 Tchem Dual specificity protein kinase CLK3 (2711 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NEK2 Tchem Serine/threonine-protein kinase NEK2 (3514 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK16 Tchem Serine/threonine-protein kinase PCTAIRE-1 (829 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STK4 Tchem Serine/threonine-protein kinase MST1 (2643 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK1D Tchem CaM kinase I delta (2141 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMK1G Tchem CaM kinase I gamma (570 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAMKK2 Tchem CaM-kinase kinase beta (1281 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 (1965 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLK Tchem Serine/threonine-protein kinase 2 (1640 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NEK6 Tchem Serine/threonine-protein kinase NEK6 (1986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PAK6 Tchem Serine/threonine-protein kinase PAK6 (1915 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIM2 Tchem Serine/threonine-protein kinase PIM2 (5873 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PAK5 Tchem Serine/threonine-protein kinase PAK7 (1760 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STK17A Tchem Serine/threonine-protein kinase 17A (1791 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TNIK Tchem TRAF2- and NCK-interacting kinase (1174 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAPAN-1 (772 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Camk2g CaM kinase II gamma (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human betaherpesvirus 5 (5122 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus (3636 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L6 (7924 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488183650
分子类型 小分子
IUPAC Name (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
INCHI InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
InChi Key NQWVSMVXKMHKTF-JKSUJKDBSA-N
Canonical SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
Isomeric SMILES COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC
WGK Germany 3
PubChem CID 64981
分子量 372.41

化学和物理性质

溶解性 溶于ethanol, 最高浓度 (mg/mL): 9.31, 最高浓度(mM): 25 温和加热；溶于DMSO, 最高浓度 (mg/mL): 37.24, 最高浓度(mM): 100
密度 1.227
比旋光度 -42° (C=1,MeOH)
熔点 100 °C
分子量 372.400 g/mol
XLogP3 3.600
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 6
可旋转键计数Rotatable Bond Count 7
精确质量Exact Mass 372.157 Da
单同位素质量Monoisotopic Mass 372.157 Da
拓扑极表面积Topological Polar Surface Area 74.200 Ų
重原子数Heavy Atom Count 27
形式电荷Formal Charge 0
复杂度Complexity 483.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3

 SDS英文版

技术规格说明书

Purity(HPLC) 98-100（%）
Infrared spectrum Conforms to Structure
Appearance(A109807) White to off-white powder
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 日期 货号
K1821016 分析证书 22-09-19 A109807
K1821015 分析证书 22-09-19 A109807
I2209317 分析证书 22-09-19 A109807
I2209318 分析证书 22-09-19 A109807
B2325317 分析证书 22-09-19 A109807

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Yang Hu, Huan Wang, Lei Liu, Jia-yun Yao, Jiong Chen.  (2022)  Evaluation on the antiviral effect of natural product arctigenin against Micropterus salmoides rhabdovirus (MSRV) in vitro and in vivo.  AQUACULTURE,  560  (738495).  [10.1016/j.aquaculture.2022.738495]
2. Jingyi Zhao, Ying Chen, Lijun Dong, Xin Li, Ruijie Dong, Dongmei Zhou, Chengzhi Wang, Xiangdong Guo, Jieyou Zhang, Zhenyi Xue, Qing Xi, Lijuan Zhang, Guangze Yang, Yan Li, Rongxin Zhang.  (2020)  Arctigenin protects mice from thioglycollate-induced acute peritonitis.  Pharmacology Research & Perspectives,  8  (5): (e00660).  [PMID:32960513] [10.1002/prp2.660]
3. Yu-Feng Shen, Yi-Hang Liu, Bo-Yang Li, Tian-Qiang Liu, Gao-Xue Wang.  (2020)  Evaluation on antiviral activity of a novel arctigenin derivative against multiple rhabdoviruses in aquaculture.  VIRUS RESEARCH,  285  (198019).  [PMID:32417180] [10.1016/j.virusres.2020.198019]
4. Wenjing Wang, Lu Wang, Lina Zou, Gaiping Li, Baoxian Ye.  (2016)  Electrochemical behavior of arctigenin at a novel voltammetric sensor based on Iodide/SWCNTs composite film modified electrode and its sensitive determination.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  772  (17).  [10.1016/j.jelechem.2016.04.002]

参考文献

1. Joshua Fischer,Aaron J Reynolds,Lisa A Sharp,Michael S Sherburn.  (2004-04-23)  Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products..  Organic letters,  6  ((9)): (1345-1348).  [PMID:15101738]
2. Shiming Liu,Kaoshan Chen,Willibald Schliemann,Dieter Strack.  (2005-05-11)  Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS..  Phytochemical analysis : PCA,  16  ((2)): (86-89).  [PMID:15881114]
3. Suresh Awale,Jie Lu,Surya K Kalauni,Yukiko Kurashima,Yasuhiro Tezuka,Shigetoshi Kadota,Hiroyasu Esumi.  (2006-02-03)  Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation..  Cancer research,  66  ((3)): (1751-1757).  [PMID:16452235]
4. Chul Young Kim,Mi-Jeong Ahn,Jinwoong Kim.  (2006-04-12)  A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography..  Journal of separation science,  29  ((5)): (656-659).  [PMID:16605084]
5. Keiichi Ishihara,Nobuyuki Yamagishi,Youhei Saito,Midori Takasaki,Takao Konoshima,Takumi Hatayama.  (2006-07-05)  Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells..  Cell stress & chaperones,  11  ((2)): (154-161).  [PMID:16817321]
6. Wenjuan Lü,Yonglei Chen,Yuxia Zhang,Xiuping Ding,Hongli Chen,Mancang Liu.  (2007-11-09)  Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  860  ((1)): (127-133).  [PMID:17988959]
7. Hyo Sook Kang,Ji Yun Lee,Chang Jong Kim.  (2008-01-09)  Anti-inflammatory activity of arctigenin from Forsythiae Fructus..  Journal of ethnopharmacology,  116  ((2)): (305-312).  [PMID:18180122]
8. Vivek Swarup,Joydeep Ghosh,Manoj Kumar Mishra,Anirban Basu.  (2008-01-31)  Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan..  The Journal of antimicrobial chemotherapy,  61  ((3)): (679-688).  [PMID:18230688]
9. Feng Zhao,Lu Wang,Ke Liu.  (2009-05-12)  In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway..  Journal of ethnopharmacology,  122  ((3)): (457-462).  [PMID:19429312]
10. Kyoko Hayashi,Kazuto Narutaki,Yasuo Nagaoka,Toshimitsu Hayashi,Shinichi Uesato.  (2010-07-08)  Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus..  Biological & pharmaceutical bulletin,  33  ((7)): (1199-1205).  [PMID:20606313]
11. Ji Yun Lee,Chang Jong Kim.  (2010-07-08)  Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes..  Archives of pharmacal research,  33  ((6)): (947-957).  [PMID:20607501]
12. He Liu,Yupu Zhang,Yantao Sun,Xue Wang,Yujuan Zhai,Ye Sun,Shuo Sun,Aimin Yu,Hanqi Zhang,Yinghua Wang.  (2010-09-03)  Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  878  ((28)): (2707-2711).  [PMID:20810325]
13. Xianjuan Kou,Shimei Qi,Wuxing Dai,Lan Luo,Zhimin Yin.  (2011-03-24)  Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway..  International immunopharmacology,  11  ((8)): (1095-1102).  [PMID:21426947]
14. Xiangyang Yao,Fenfen Zhu,Zhihui Zhao,Chang Liu,Lan Luo,Zhimin Yin.  (2011-05-25)  Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway..  Journal of cellular biochemistry,  112  ((10)): (2837-2849).  [PMID:21608020]
15. Jin Boo Jeong,Se Chul Hong,Hyung Jin Jeong,Jin Suk Koo.  (2011-05-31)  Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells..  International immunopharmacology,  11  ((10)): (1573-1577).  [PMID:21621647]
16. Chen Gui-Rong,Cai Li-Ping,Dou De-Qiang,Kang Ting-Guo,Li Hong-Fu,Li Fu-Rui,Jiang Ning.  (2011-08-27)  Synthesis of (-)-arctigenin derivatives and their anticancer activity..  Natural product research,  26  ((2)): (177-181).  [PMID:21867457]
17. C Miele,F Beguinot.  (2012-02-24)  New expectations from the well-known medicinal properties of Arctium lappa..  Diabetologia,  55  ((5)): (1244-1246).  [PMID:22358500]
18. A-Ram Kim,Hyuk Soon Kim,Jeong Min Lee,Jung Ho Choi,Se Na Kim,Do Kyun Kim,Ji Hyung Kim,Se Hwan Mun,Jie Wan Kim,Hyun Soo Jeon,Young Mi Kim,Wahn Soo Choi.  (2012-03-06)  Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages..  European journal of pharmacology,  682  ((1-3)): (29-36).  [PMID:22387094]
19. Daquan Chen,Kaoxiang Sun,Hongjie Mu,Mingtan Tang,Rongcai Liang,Aiping Wang,Shasha Zhou,Haijun Sun,Feng Zhao,Jianwen Yao,Wanhui Liu.  (2012-06-09)  pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system..  International journal of nanomedicine,  7  (2621-2630).  [PMID:22679372]
20. Yuan Gu,Chunting Qi,Xiaoxiao Sun,Xiuquan Ma,Haohao Zhang,Lihong Hu,Junying Yuan,Qiang Yu.  (2012-06-13)  Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism..  Biochemical pharmacology,  84  ((4)): (468-476).  [PMID:22687625]
21. Yuan Gu,Xiao-xiao Sun,Ji-ming Ye,Li He,Shou-sheng Yan,Hao-hao Zhang,Li-hong Hu,Jun-ying Yuan,Qiang Yu.  (2012-06-19)  Arctigenin alleviates ER stress via activating AMPK..  Acta pharmacologica Sinica,  33  ((7)): (941-952).  [PMID:22705729]
22. Li-Ying Zhang,Yi-Shun Yang,Tong Zhang,Yue Ding,Zhen-Zhen Cai,Jian-Sheng Tao.  (2012-08-11)  [Research on the preparative method of Arctigenin]..  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,  35  ((3)): (467-470).  [PMID:22876688]
23. Tao Fan,Wei Long Jiang,Jian Zhu,Yu Feng Zhang.  (2012-09-14)  Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation..  Biological & pharmaceutical bulletin,  35  ((11)): (2004-2009).  [PMID:22972486]
24. Kevin Lai,Douglas W Selinger,Jonathan M Solomon,Hua Wu,Esther Schmitt,Fabrizio C Serluca,Daniel Curtis,John D Benson.  (2012-11-10)  Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin..  ACS chemical biology,  8  ((1)): (257-267).  [PMID:23138533]
25. Jong-Sik Jin,Jong-Hyun Lee,Masao Hattori.  (2013-01-18)  Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha..  Molecules (Basel, Switzerland),  18  ((1)): (1122-1127).  [PMID:23325100]
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