别嘌醇, 黄嘌呤脱氢酶抑制剂

黄嘌呤氧化酶抑制剂
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货号 (SKU) 包装规格 是否现货 价格 数量
A105386-5g
5g 现货 Stock Image
A105386-10g
10g 现货 Stock Image
A105386-25g
25g 现货 Stock Image
A105386-100g
100g 现货 Stock Image
A105386-500g
500g 现货 Stock Image

基本描述

别名 别嘌呤醇 | 4-羟基吡唑并[3,4-d]嘧啶 | 1H-吡唑并[3,4-d]嘧啶-4-醇
英文别名 HPP | 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro- | Dabrosin | DTXSID50892275 | Xanturat | 4-Hydroxypyrazolyl(3,4-d)pyrimidine | O11481 | Zyloric | 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one | 1H-pyrazolo[3,4-d]pyrimidin-4(2H)-one | 4-Hydroxypyrazo
规格或纯度 Moligand™, ≥98%
英文名称 Allopurinol
生化机理 黄嘌呤氧化酶抑制剂(IC 50 = 0.2-50μM)。抗高尿酸嘌呤类似物。抑制体内尿酸的产生。具有神经保护作用。体内具有活性
运输条件 常规运输
作用类型 抑制剂
作用机制 黄嘌呤脱氢酶抑制剂
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。有毒,请参阅SDS以获取更多信息。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍

Allopurinol is an anti-urolithic Xanthine oxidase inhibitor that decreases uric acid production.黄嘌呤氧化酶(xanthine oxidase) 和吡啶合成的抑制剂。

Allopurinol is an anti-urolithic Xanthine oxidase inhibitor that decreases uric acid production.
An anti-urolithic Xanthine oxidase inhibitor

AI解读

关联靶点(人)

XDH Tclin 黄嘌呤脱氢酶/氧化酶(Xanthine dehydrogenase/oxidase) (11 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pnp Purine nucleoside phosphorylase (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pneumocystis carinii (749 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania infantum (5912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Entamoeba histolytica (2676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptosporidium parvum (1150 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania amazonensis (3813 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania major (2877 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania mexicana (936 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei rhodesiense (7991 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
J774.A1 (2436 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-12 (7051 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus anthracis (2936 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Xdh Xanthine dehydrogenase/oxidase (52 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
stxA Shiga toxin subunit A (82 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Peritoneal macrophage (1554 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504773260
EC号 206-250-9
分子类型 小分子
IUPAC Name 1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one
INCHI InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
InChi Key OFCNXPDARWKPPY-UHFFFAOYSA-N
Canonical SMILES C1=NNC2=C1C(=O)NC=N2
Isomeric SMILES C1=NNC2=C1C(=O)NC=N2
WGK Germany 2
RTECS UR0785000
PubChem CID 135401907
UN Number 2811
Packing Group I
分子量 136.11
Beilstein号 26(3/4)4298
Reaxy-Rn 608611

化学和物理性质

溶解性 不溶于水;水中溶解度:0.48 g/l 25 °C;不溶于氯仿、乙醚、乙醇;1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
密度 1.89
熔点 384°C
分子量 136.110 g/mol
XLogP3 -0.700
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 136.039 Da
单同位素质量Monoisotopic Mass 136.039 Da
拓扑极表面积Topological Polar Surface Area 70.100 Ų
重原子数Heavy Atom Count 10
形式电荷Formal Charge 0
复杂度Complexity 190.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS06,   GHS07
信号词 Danger
危险声明

H301: 吞咽会中毒

H317: 可能引起皮肤过敏反应

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染:用水充分清洗。

P321: 特殊处理(请参阅此标签上的...)。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P270: 使用本产品时,请勿进食、饮水或吸烟。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。

P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。

P330: 漱口

P301+P316: 如果吞咽:立即寻求紧急医疗救助。

WGK Germany 2
RTECS UR0785000
Reaxy-Rn 608611
Class 6.1
Merck Index 279
个人防护装备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

技术规格说明书

Carbon by Elemental Analysis 43.1-45.3(%)
Purity(HPLC) 98-100(%)
Purity(Neutralization titration) 97.5-102.5(%)
Nitrogen by Elemental Analysis 40.1-42.1(%)
Appearance(A105386) White to Off-White Powder
Infrared spectrum Conforms to Structure
Proton NMR spectrum Conforms to Structure
Solubility in 1M NaOH,Colorless to Yellow,Clear to Slightly Hazy,50mg/ml pass

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到28个结果

批号(Lot Number) 证书类型 日期 货号
E2508106 分析证书 25-04-17 A105386
E2508107 分析证书 25-04-17 A105386
E2508108 分析证书 25-04-17 A105386
E2508109 分析证书 25-04-17 A105386
C2521219 分析证书 24-12-02 A105386
L2410261 分析证书 24-12-02 A105386
L2410267 分析证书 24-12-02 A105386
D2420008 分析证书 24-03-26 A105386
C2521208 分析证书 24-03-11 A105386
D2403684 分析证书 24-03-11 A105386
D2403683 分析证书 24-03-11 A105386
K2420145 分析证书 22-02-26 A105386
C2215351 分析证书 22-02-26 A105386
C2215368 分析证书 22-02-26 A105386
C2215377 分析证书 22-02-26 A105386
C2215381 分析证书 22-02-26 A105386
E2310740 分析证书 22-02-26 A105386
E2310743 分析证书 22-02-26 A105386
E2326331 分析证书 22-02-26 A105386
G2307492 分析证书 22-02-26 A105386
G2319050 分析证书 22-02-26 A105386
H2329112 分析证书 22-02-26 A105386
J2323105 分析证书 22-02-26 A105386
K2301038 分析证书 22-02-26 A105386
K2301039 分析证书 22-02-26 A105386
D2418065 分析证书 22-02-26 A105386
J2129366 分析证书 21-11-02 A105386
A2221059 分析证书 21-11-02 A105386

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此产品的引用文献

1. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li.  (2023)  Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.  PHYTOMEDICINE,  (155305).  [PMID:38176275] [10.1016/j.phymed.2023.155305]
2. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu.  (2023)  Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  [PMID:21153684] [10.1111/ijfs.16731]
3. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang.  (2023)  Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction.  Marine Drugs,  21  (10): (502).  [PMID:37888437] [10.3390/md21100502]
4. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang.  (2023)  In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate.  FOOD AND CHEMICAL TOXICOLOGY,  177  (113854).  [PMID:37230458] [10.1016/j.fct.2023.113854]
5. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi.  (2023)  Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  299  (122861).  [PMID:37209475] [10.1016/j.saa.2023.122861]
6. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin.  (2023)  Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies.  IET Nanobiotechnology,  17  (4): (368-375).  [PMID:37153957] [10.1049/nbt2.12135]
7. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang.  (2023)  Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein.  FOOD RESEARCH INTERNATIONAL,  169  (112882).  [PMID:37254330] [10.1016/j.foodres.2023.112882]
8. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang.  (2023)  In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  232  (115415).  [PMID:37120975] [10.1016/j.jpba.2023.115415]
9. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang.  (2023)  Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase.  BIOORGANIC CHEMISTRY,  133  (106394).  [PMID:36801789] [10.1016/j.bioorg.2023.106394]
10. Yingling Sui, Deping Xu, Xiulan Sun.  (2023)  Identification of anti-hyperuricemic components from Coix seed.  Food Bioscience,  52  (102461).  [10.1016/j.fbio.2023.102461]
11. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich.  (2023)  Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels.  Biomaterials Science,  11  (5): (1704-1713).  [PMID:36628631] [10.1039/D2BM01836E]
12. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu.  (2022)  Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz.  Food & Function,  13  (22): (11780-11793).  [PMID:36300542] [10.1039/D2FO01854C]
13. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing.  (2022)  Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.  Frontiers in Pharmacology,  13  [PMID:36120294] [10.3389/fphar.2022.950699]
14. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei.  (2022)  Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  276  (121219).  [PMID:35397450] [10.1016/j.saa.2022.121219]
15. Rui Sun, Juan Kan, Huahao Cai, Jinhai Hong, Changhai Jin, Man Zhang.  (2022)  In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  46  (2): (e14049).  [PMID:34981522] [10.1111/jfbc.14049]
16. Liyan Yuan, Zhijie Bao, Tiecheng Ma, Songyi Lin.  (2021)  Hypouricemia effects of corn silk flavonoids in a mouse model of potassium oxonated-induced hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  45  (8): (e13856).  [PMID:34250618] [10.1111/jfbc.13856]
17. Yin Wan, Jin Qian, Yizhen Li, Yuefeng Shen, Yanru Chen, Guiming Fu, Mingyong Xie.  (2021)  Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  184  (843).  [PMID:34146563] [10.1016/j.ijbiomac.2021.06.075]
18. Caixin Ni, Xin Li, Linlin Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen.  (2021)  Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism.  Food & Function,  12  (15): (7054-7067).  [PMID:34152353] [10.1039/D1FO00198A]
19. Shi Feng, Chen Lin, Wang Yaping, Liu Jing, Adu-Frimpong Michael, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system.  Drug Delivery and Translational Research,  12  (3): (603-614).  [PMID:33860450] [10.1007/s13346-021-00969-8]
20. Xie Jiahong, Cui Haoxin, Xu Yang, Xie Lianghua, Chen Wei.  (2021)  Delphinidin-3-O-sambubioside: a novel xanthine oxidase inhibitor identified from natural anthocyanins.  Food Quality and Safety,  [10.1093/fqsafe/fyaa038]
21. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259] [10.1039/D0FO03059G]
22. Yanzuo Le, Xie Zhou, Jiawen Zheng, Fangmiao Yu, Yunping Tang, Zuisu Yang, Guofang Ding, Yan Chen.  (2020)  Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.  Marine Drugs,  18  (12): (610).  [PMID:33271765] [10.3390/md18120610]
23. Yi Tao, Lin Chen, Enci Jiang.  (2021)  Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by surface plasmon resonance biosensor validation.  ANALYTICA CHIMICA ACTA,  1146  (155).  [PMID:33461711] [10.1016/j.aca.2020.11.016]
24. Xingchu Gong, Jingyuan Shao, Shangxin Guo, Jingjing Pan, Xiaohui Fan.  (2021)  Determination of inhibitory activity of Salvia miltiorrhiza extracts on xanthine oxidase with a paper-based analytical device.  Journal of Pharmaceutical Analysis,  11  (603).  [PMID:34765273] [10.1016/j.jpha.2020.09.004]
25. Xiao-Wei Zhang, Mei Zhou, Lin An, Ping Zhang, Ping Li, Jun Chen.  (2020)  Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways.  AMERICAN JOURNAL OF CHINESE MEDICINE,  48  (6): (1455-1473).  [PMID:32933312] [10.1142/S0192415X20500718]
26. Wen Weng, Qilong Wang, Chunmei Wei, Na Man, Kangyi Zhang, Qiuyu Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu.  (2019)  Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  572  (118735).  [PMID:31705971] [10.1016/j.ijpharm.2019.118735]
27. Zhang Kangyi, Wang Qilong, Yang Qiuxuan, Wei Qiuyu, Man Na, Adu-Frimpong Michael, Toreniyazov Elmurat, Ji Hao, Yu Jiangnan, Xu Ximing.  (2019)  Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System.  AAPS PHARMSCITECH,  20  (5): (1-11).  [PMID:31187334] [10.1208/s12249-019-1421-0]
28. Yin Wan, Fen Wang, Bin Zou, Yuefeng Shen, Yizhen Li, Axi Zhang, Guiming Fu.  (2019)  Molecular mechanism underlying the ability of caffeic acid to decrease uric acid levels in hyperuricemia rats.  Journal of Functional Foods,  57  (150).  [10.1016/j.jff.2019.03.038]
29. Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Huiping Hu, Dan Zuo, Danling Liang.  (2018)  Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.  AMERICAN JOURNAL OF CHINESE MEDICINE,  46  (3): (585-599).  [PMID:29595077] [10.1142/S0192415X18500301]
30. Yin Wan, Yu-Xi Liang, Bin Zou, Gui-Ming Fu, Ming-Yong Xie.  (2018)  The possible mechanism of hydroxytyrosol on reducing uric acid levels.  Journal of Functional Foods,  42  (319).  [10.1016/j.jff.2018.01.009]
31. Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu.  (2017)  Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.  JOURNAL OF SEPARATION SCIENCE,  40  (21): (4160-4167).  [PMID:28857450] [10.1002/jssc.201700690]
32. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan.  (2017)  Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.  JOURNAL OF FOOD BIOCHEMISTRY,  41  (4): (e12377).  [10.1111/jfbc.12377]
33. Hongjin Tang, Lin Yang, Wei Li, Jiahuang Li, Jun Chen.  (2016)  Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking.  RSC Advances,  (114): (113527-113537).  [10.1039/C6RA24396G]
34. Yin Wan, Bin Zou, Hailong Zeng, Lunning Zhang, Ming Chen, Guiming Fu.  (2016)  Inhibitory effect of verbascoside on xanthine oxidase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  93  (609).  [PMID:27616694] [10.1016/j.ijbiomac.2016.09.022]
35. Fu Yu, Mo Hua-Yan, Gao Wen, Hong Jia-Ying, Lu Jun, Li Ping, Chen Jun.  (2014)  Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  406  (20): (4987-4995).  [PMID:24866714] [10.1007/s00216-014-7902-9]

参考文献

1. Pini M et al..  (2021)  Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure..  Aging Cell,  20  (8): (e13421).  [PMID:34278707]
2. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li.  (2023)  Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.  PHYTOMEDICINE,  (155305).  [PMID:38176275] [10.1016/j.phymed.2023.155305]
3. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu.  (2023)  Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  [PMID:21153684] [10.1111/ijfs.16731]
4. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang.  (2023)  Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction.  Marine Drugs,  21  (10): (502).  [PMID:37888437] [10.3390/md21100502]
5. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang.  (2023)  In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate.  FOOD AND CHEMICAL TOXICOLOGY,  177  (113854).  [PMID:37230458] [10.1016/j.fct.2023.113854]
6. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi.  (2023)  Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  299  (122861).  [PMID:37209475] [10.1016/j.saa.2023.122861]
7. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin.  (2023)  Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies.  IET Nanobiotechnology,  17  (4): (368-375).  [PMID:37153957] [10.1049/nbt2.12135]
8. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang.  (2023)  Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein.  FOOD RESEARCH INTERNATIONAL,  169  (112882).  [PMID:37254330] [10.1016/j.foodres.2023.112882]
9. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang.  (2023)  In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  232  (115415).  [PMID:37120975] [10.1016/j.jpba.2023.115415]
10. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang.  (2023)  Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase.  BIOORGANIC CHEMISTRY,  133  (106394).  [PMID:36801789] [10.1016/j.bioorg.2023.106394]
11. Yingling Sui, Deping Xu, Xiulan Sun.  (2023)  Identification of anti-hyperuricemic components from Coix seed.  Food Bioscience,  52  (102461).  [10.1016/j.fbio.2023.102461]
12. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich.  (2023)  Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels.  Biomaterials Science,  11  (5): (1704-1713).  [PMID:36628631] [10.1039/D2BM01836E]
13. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu.  (2022)  Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz.  Food & Function,  13  (22): (11780-11793).  [PMID:36300542] [10.1039/D2FO01854C]
14. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing.  (2022)  Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.  Frontiers in Pharmacology,  13  [PMID:36120294] [10.3389/fphar.2022.950699]
15. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei.  (2022)  Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  276  (121219).  [PMID:35397450] [10.1016/j.saa.2022.121219]
16. Rui Sun, Juan Kan, Huahao Cai, Jinhai Hong, Changhai Jin, Man Zhang.  (2022)  In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  46  (2): (e14049).  [PMID:34981522] [10.1111/jfbc.14049]
17. Liyan Yuan, Zhijie Bao, Tiecheng Ma, Songyi Lin.  (2021)  Hypouricemia effects of corn silk flavonoids in a mouse model of potassium oxonated-induced hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  45  (8): (e13856).  [PMID:34250618] [10.1111/jfbc.13856]
18. Yin Wan, Jin Qian, Yizhen Li, Yuefeng Shen, Yanru Chen, Guiming Fu, Mingyong Xie.  (2021)  Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  184  (843).  [PMID:34146563] [10.1016/j.ijbiomac.2021.06.075]
19. Caixin Ni, Xin Li, Linlin Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen.  (2021)  Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism.  Food & Function,  12  (15): (7054-7067).  [PMID:34152353] [10.1039/D1FO00198A]
20. Shi Feng, Chen Lin, Wang Yaping, Liu Jing, Adu-Frimpong Michael, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system.  Drug Delivery and Translational Research,  12  (3): (603-614).  [PMID:33860450] [10.1007/s13346-021-00969-8]
21. Xie Jiahong, Cui Haoxin, Xu Yang, Xie Lianghua, Chen Wei.  (2021)  Delphinidin-3-O-sambubioside: a novel xanthine oxidase inhibitor identified from natural anthocyanins.  Food Quality and Safety,  [10.1093/fqsafe/fyaa038]
22. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259] [10.1039/D0FO03059G]
23. Yanzuo Le, Xie Zhou, Jiawen Zheng, Fangmiao Yu, Yunping Tang, Zuisu Yang, Guofang Ding, Yan Chen.  (2020)  Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.  Marine Drugs,  18  (12): (610).  [PMID:33271765] [10.3390/md18120610]
24. Yi Tao, Lin Chen, Enci Jiang.  (2021)  Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by surface plasmon resonance biosensor validation.  ANALYTICA CHIMICA ACTA,  1146  (155).  [PMID:33461711] [10.1016/j.aca.2020.11.016]
25. Xingchu Gong, Jingyuan Shao, Shangxin Guo, Jingjing Pan, Xiaohui Fan.  (2021)  Determination of inhibitory activity of Salvia miltiorrhiza extracts on xanthine oxidase with a paper-based analytical device.  Journal of Pharmaceutical Analysis,  11  (603).  [PMID:34765273] [10.1016/j.jpha.2020.09.004]
26. Xiao-Wei Zhang, Mei Zhou, Lin An, Ping Zhang, Ping Li, Jun Chen.  (2020)  Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways.  AMERICAN JOURNAL OF CHINESE MEDICINE,  48  (6): (1455-1473).  [PMID:32933312] [10.1142/S0192415X20500718]
27. Wen Weng, Qilong Wang, Chunmei Wei, Na Man, Kangyi Zhang, Qiuyu Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu.  (2019)  Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  572  (118735).  [PMID:31705971] [10.1016/j.ijpharm.2019.118735]
28. Zhang Kangyi, Wang Qilong, Yang Qiuxuan, Wei Qiuyu, Man Na, Adu-Frimpong Michael, Toreniyazov Elmurat, Ji Hao, Yu Jiangnan, Xu Ximing.  (2019)  Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System.  AAPS PHARMSCITECH,  20  (5): (1-11).  [PMID:31187334] [10.1208/s12249-019-1421-0]
29. Yin Wan, Fen Wang, Bin Zou, Yuefeng Shen, Yizhen Li, Axi Zhang, Guiming Fu.  (2019)  Molecular mechanism underlying the ability of caffeic acid to decrease uric acid levels in hyperuricemia rats.  Journal of Functional Foods,  57  (150).  [10.1016/j.jff.2019.03.038]
30. Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Huiping Hu, Dan Zuo, Danling Liang.  (2018)  Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.  AMERICAN JOURNAL OF CHINESE MEDICINE,  46  (3): (585-599).  [PMID:29595077] [10.1142/S0192415X18500301]
31. Yin Wan, Yu-Xi Liang, Bin Zou, Gui-Ming Fu, Ming-Yong Xie.  (2018)  The possible mechanism of hydroxytyrosol on reducing uric acid levels.  Journal of Functional Foods,  42  (319).  [10.1016/j.jff.2018.01.009]
32. Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu.  (2017)  Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.  JOURNAL OF SEPARATION SCIENCE,  40  (21): (4160-4167).  [PMID:28857450] [10.1002/jssc.201700690]
33. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan.  (2017)  Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.  JOURNAL OF FOOD BIOCHEMISTRY,  41  (4): (e12377).  [10.1111/jfbc.12377]
34. Hongjin Tang, Lin Yang, Wei Li, Jiahuang Li, Jun Chen.  (2016)  Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking.  RSC Advances,  (114): (113527-113537).  [10.1039/C6RA24396G]
35. Yin Wan, Bin Zou, Hailong Zeng, Lunning Zhang, Ming Chen, Guiming Fu.  (2016)  Inhibitory effect of verbascoside on xanthine oxidase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  93  (609).  [PMID:27616694] [10.1016/j.ijbiomac.2016.09.022]
36. Fu Yu, Mo Hua-Yan, Gao Wen, Hong Jia-Ying, Lu Jun, Li Ping, Chen Jun.  (2014)  Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  406  (20): (4987-4995).  [PMID:24866714] [10.1007/s00216-014-7902-9]

溶液计算器