计算溶液所需的质量、体积或浓度。
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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A101337-5g |
5g |
现货 ![]() |
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A101337-25g |
25g |
现货 ![]() |
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A101337-100g |
100g |
现货 ![]() |
| |
A101337-500g |
500g |
现货 ![]() |
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A101337-2.5kg |
2.5kg |
现货 ![]() |
|
别名 | 6-氨基青霉素酸 |
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英文别名 | FLUCLOXACILLIN SODIUM MONOHYDRATE IMPURITY C [EP IMPURITY] | PHENOXYMETHYLPENICILLIN IMPURITY C [EP IMPURITY] | SR-01000640154-1 | Flucloxacillin impurity C, European Pharmacopoeia (EP) Reference Standard | NSC-50071 | SULBACTAM SODIUM IMPURITY B [EP IMPU |
规格或纯度 | ≥98% |
英文名称 | (+)-6-Aminopenicillanic acid |
应用 | 制备半合成青霉素的原料。 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
产品介绍 |
微溶于水,不溶于乙酸丁酯、乙醇或丙酮。遇碱分解,对酸较稳定。 |
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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PubChem SID | 504752056 |
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EC号 | 208-993-4 |
分子类型 | 小分子 |
IUPAC Name | (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
INCHI | InChI=1S/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1 |
InChi Key | NGHVIOIJCVXTGV-ALEPSDHESA-N |
Canonical SMILES | CC1(C(N2C(S1)C(C2=O)N)C(=O)O)C |
Isomeric SMILES | CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N)C(=O)O)C |
WGK Germany | 2 |
RTECS | XH8225000 |
PubChem CID | 11082 |
分子量 | 216.26 |
Beilstein号 | 15080 |
Reaxy-Rn | 15080 |
密度 | 1.52 |
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比旋光度 | 275° (C=1.2,0.1mol/L HCl) |
熔点 | 198-200°C |
分子量 | 216.260 g/mol |
XLogP3 | -2.100 |
氢键供体数Hydrogen Bond Donor Count | 2 |
氢键受体数Hydrogen Bond Acceptor Count | 5 |
可旋转键计数Rotatable Bond Count | 1 |
精确质量Exact Mass | 216.057 Da |
单同位素质量Monoisotopic Mass | 216.057 Da |
拓扑极表面积Topological Polar Surface Area | 109.000 Ų |
重原子数Heavy Atom Count | 14 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 318.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS08 |
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信号词 | Danger |
危险声明 |
H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P342+P311: 如有呼吸系统病症:呼叫急救中心/医生。 P302+P352: 如皮肤沾染:用水充分清洗。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P403: 存放在通风良好的地方。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。 P330: 漱口 P285: 如果通风不良,请佩戴呼吸防护装置。 P304+P341: 如果吸入:如果呼吸困难,请将患者转移到新鲜空气处并保持呼吸舒适的休息姿势。 P301+P312: 如误吞咽:如感觉不适,呼叫急救中心/医生。 |
WGK Germany | 2 |
RTECS | XH8225000 |
Reaxy-Rn | 15080 |
Merck Index | 458 |
个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
Specific Rotation [a]20/D(c=1.2 in 0.1mol/L HCl) | 270-280(°) |
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Melting point | 197-200(℃) |
Purity(HPLC) | 98-100(%) |
Purity(Neutralization titration) | 97.5-102.5(%) |
Appearance(A101337) | White to yellow powder or crystals |
Infrared spectrum | Conforms to Structure |
Solubility in 1 M HCl | Almost transparency |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
批号(Lot Number) | 证书类型 | 日期 | 货号 |
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分析证书 | 24-04-02 | A101337 |
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分析证书 | 24-04-02 | A101337 |
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分析证书 | 24-01-30 | A101337 |
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分析证书 | 23-02-27 | A101337 |
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分析证书 | 23-02-27 | A101337 |
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分析证书 | 23-02-27 | A101337 |
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分析证书 | 22-12-22 | A101337 |
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分析证书 | 21-05-28 | A101337 |
1. Yixiang Cai, Hong Yu, Liheng Ren, Yingjuan Ou, Shilin Jiang, Youzheng Chai, Anwei Chen, Binghua Yan, Jiachao Zhang, Zhiyong Yan. (2023) Treatment of amoxicillin-containing wastewater by Trichoderma strains selected from activated sludge. SCIENCE OF THE TOTAL ENVIRONMENT, 867 (161565). [PMID:36642266] [10.1016/j.scitotenv.2023.161565] |
2. Chang Sun, Jian Lu, Yilin Wu, Minjia Meng, Chao Yu, Zeqing Dong, Muning Chen, Yongsheng Yan, Yan Sun. (2020) Imitated Core-Shell Molecularly Imprinted Membranes for Selective Separation Applications: A Synergetic Strategy by Polydopamine and SiO2. Journal of the Taiwan Institute of Chemical Engineers, 115 (304). [10.1016/j.jtice.2020.10.016] |
3. Yanyan Zhao, Huanxian Shi, Xiaoyun Hu, Enzhou Liu, Jun Fan. (2020) Fabricating CsPbX3/CN heterostructures with enhanced photocatalytic activity for penicillins 6-APA degradation. CHEMICAL ENGINEERING JOURNAL, 381 (122692). [10.1016/j.cej.2019.122692] |
4. Zhang Xiao-Li, Zong Min-Hua, Li Ning. (2016) Penicillin acylase-catalyzed synthesis of N-bromoacetyl-7-aminocephalosporanic acid, the key intermediate for the production of cefathiamidine. Bioresources and Bioprocessing, 3 (1): (1-8). [PMID:27917366] [10.1186/s40643-016-0127-3] |
5. Yuan-Ting Li, Lu-Lu Qu, Da-Wei Li, Qi-Xia Song, Farkhondeh Fathi, Yi-Tao Long. (2013) Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag–graphene sensor based on electrophoretic preconcentration and surface-enhanced Raman spectroscopy. BIOSENSORS & BIOELECTRONICS, 43 (94). [PMID:23287654] [10.1016/j.bios.2012.12.005] |
1. G N Rolinson,A M Geddes. (2006-12-02) The 50th anniversary of the discovery of 6-aminopenicillanic acid (6-APA).. International journal of antimicrobial agents, 29 ((1)): (3-8). [PMID:17137753] |
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3. Yangyang Jiang,Hansong Xia,Chen Guo,Iram Mahmood,Huizhou Liu. (2008-05-06) Enzymatic hydrolysis of penicillin for 6-APA production in three-liquid-phase system.. Applied biochemistry and biotechnology, 144 ((2)): (145-159). [PMID:18456946] |
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5. Rubina Arshad,Shafqat Farooq,Syed Shahid Ali. (2008-12-19) Comparative production of 6-aminopenicillanic acid by different E. coli strains and their acridine orange (AO) induced mutants.. Pakistan journal of biological sciences : PJBS, 10 ((21)): (3931-3935). [PMID:19090257] |
6. Louis Anthony Tony Cox,Douglas A Popken,Jeremy J Mathers. (2009-06-06) Human health risk assessment of penicillin/aminopenicillin resistance in enterococci due to penicillin use in food animals.. Risk analysis : an official publication of the Society for Risk Analysis, 29 ((6)): (796-805). [PMID:19490520] |
7. José Luis Martínez-Hernández,Marco Arnulfo Mata-Gómez,Cristóbal Noé Aguilar-González,Anna Ilyina. (2009-09-22) A process to produce penicillin G acylase by surface-adhesion fermentation using Mucor griseocyanus to obtain 6-aminopenicillanic acid by penicillin G hydrolysis.. Applied biochemistry and biotechnology, 160 ((7)): (2045-2053). [PMID:19768388] |
8. Shu-Guang Fang,Tan Qiang,Rui-Jiang Liu,Xi-Ming Xu,Ye-Wang Zhang. (2009-12-22) Enhanced production of 6-aminopenicillanic acid in aqueous methyl isobutyl ketone system with immobilized penicillin G acylase.. Preparative biochemistry & biotechnology, 40 ((1)): (38-45). [PMID:20024793] |
9. Ye-Wang Zhang,Rui-Jiang Liu,Xi-Ming Xu. (2010-06-23) One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+.. Applied microbiology and biotechnology, 88 ((1)): (49-55). [PMID:20567815] |
10. Nolwenn Coquart,Ingrid Kupfer-Bessaguet,Frédéric Staroz,Patrice Plantin. (2010-07-16) Acute generalized exanthematous pustulosis (AGEP) induced by terbinafine and two different antibiotics: four recurrences.. European journal of dermatology : EJD, 20 ((5)): (638-639). [PMID:20627850] |
11. Junqi Zhao,Yujun Wang,Guangsheng Luo,Shenlin Zhu. (2010-10-23) Immobilization of penicillin G acylase on macro-mesoporous silica spheres.. Bioresource technology, 102 ((2)): (529-535). [PMID:20965720] |
12. Zhiqiang Chen,Hongcheng Wang,Zhaobo Chen,Nanqi Ren,Aijie Wang,Yue Shi,Xiaoming Li. (2010-10-26) Performance and model of a full-scale up-flow anaerobic sludge blanket (UASB) to treat the pharmaceutical wastewater containing 6-APA and amoxicillin.. Journal of hazardous materials, 185 ((2-3)): (905-913). [PMID:20970923] |
13. J-L Schmutz,A Barbaud,P Trechot. (2011-05-17) [Four recurrences of acute generalized exanthematous pustulosis (AGEP) with three different drugs in the same patient].. Annales de dermatologie et de venereologie, 138 ((5)): (456-456). [PMID:21570578] |
14. V B Kurochkina,A V Sklyarenko,J E Satarova,S V Yarotsky. (2011-06-24) Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins.. Bioprocess and biosystems engineering, 34 ((9)): (1103-1117). [PMID:21698348] |
15. Cătălina Daniela Stan,Alina Stefanache,Maria Drăgan,Antonia Poiată,D E Diaconu,Lenuţa Profire. (2011-11-04) [Research for the improvement of acylation conditions in antistaphylococcal penicillin synthesis].. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 115 ((3)): (972-977). [PMID:22046818] |
16. Faridoon,Waleed M Hussein,Nazar Ul Islam,Luke W Guddat,Gerhard Schenk,Ross P McGeary. (2012-03-01) Penicillin inhibitors of purple acid phosphatase.. Bioorganic & medicinal chemistry letters, 22 ((7)): (2555-2559). [PMID:22366658] |
17. Joanna Skiba,Aleksandra Rajnisz,Kely Navakoski de Oliveira,Ingo Ott,Jolanta Solecka,Konrad Kowalski. (2012-10-18) Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid--synthesis, electrochemistry and biological activity.. European journal of medicinal chemistry, 57 (234-239). [PMID:23072737] |
18. Lucie Vobecká,Alexandr Romanov,Zdeněk Slouka,Pavel Hasal,Michal Přibyl. (2018-04-04) Optimization of aqueous two-phase systems for the production of 6-aminopenicillanic acid in integrated microfluidic reactors-separators.. New biotechnology, 47 (73-79). [PMID:29614323] |
19. Terence S Crofts,Bin Wang,Aaron Spivak,Tara A Gianoulis,Kevin J Forsberg,Molly K Gibson,Lauren A Johnsky,Stacey M Broomall,C Nicole Rosenzweig,Evan W Skowronski,Henry S Gibbons,Morten O A Sommer,Gautam Dantas. (2018-05-02) Shared strategies for β-lactam catabolism in the soil microbiome.. Nature chemical biology, 14 ((6)): (556-564). [PMID:29713061] |
20. Alexandr Romanov,Zdeněk Slouka,Michal Přibyl. (2020-10-14) Electric-field-enhanced selective separation of products of an enzymatic reaction in a membrane micro-contactor.. Biotechnology and bioengineering, 118 ((2)): (715-724). [PMID:33049066] |
21. G N Rolinson. (1988-07-01) The Garrod lecture. The influence of 6-aminopenicillanic acid on antibiotic development.. The Journal of antimicrobial chemotherapy, 22 ((1)): (5-14). [PMID:2844714] |
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25. David A Harris,Michael E Powers,Floyd E Romesberg. (2009-05-12) Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase.. Bioorganic & medicinal chemistry letters, 19 ((14)): (3787-3790). [PMID:19427205] |
26. Edson Romano Nucci,Antonio J G Cruz,Roberto C Giordano. (2009-09-04) Monitoring bioreactors using principal component analysis: production of penicillin G acylase as a case study.. Bioprocess and biosystems engineering, 33 ((5)): (557-564). [PMID:19727832] |
27. J Swaminathan,M Ramalingam,V Sethuraman,N Sundaraganesan,S Sebastian,M Kurt. (2009-11-10) FT-IR, FT-Raman, ab initio and DFT structural and vibrational frequency analysis of 6-aminopenicillanic acid.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75 ((1)): (183-190). [PMID:19897407] |
28. A K Dolui,S Das. (2011-05-28) Comparative study of 6-APA production by free and agar immobilized bacteria in nutrient broth culture.. Indian journal of experimental biology, 49 ((4)): (289-292). [PMID:21614893] |
29. Chunqiu Tian,Huarong Tan,Liping Gao,Huqin Shen,Kezong Qi. (2012-03-08) [Determination of penicillin intermediate and three penicillins in milk by high performance capillary electrophoresis].. Se pu = Chinese journal of chromatography, 29 ((11)): (1128-1132). [PMID:22393704] |
30. Francesco Crea,Daniela Cucinotta,Concetta De Stefano,Demetrio Milea,Silvio Sammartano,Giuseppina Vianelli. (2012-08-21) Modeling solubility, acid-base properties and activity coefficients of amoxicillin, ampicillin and (+)6-aminopenicillanic acid, in NaCl(aq) at different ionic strengths and temperatures.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47 ((4)): (661-677). [PMID:22903046] |
31. Anand Pai,Yu Tanouchi,Lingchong You. (2012-11-13) Optimality and robustness in quorum sensing (QS)-mediated regulation of a costly public good enzyme.. Proceedings of the National Academy of Sciences of the United States of America, 109 ((48)): (19810-19815). [PMID:23144221] |
32. Guolin Li,Cen Xie,Siyu Lu,Robert G Nichols,Yuan Tian,Licen Li,Daxeshkumar Patel,Yinyan Ma,Chad N Brocker,Tingting Yan,Kristopher W Krausz,Rong Xiang,Oksana Gavrilova,Andrew D Patterson,Frank J Gonzalez. (2017-09-19) Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut\xa0Microbiota.. Cell metabolism, 26 ((4)): (672-685). [PMID:28918936] |
33. Yixiang Cai, Hong Yu, Liheng Ren, Yingjuan Ou, Shilin Jiang, Youzheng Chai, Anwei Chen, Binghua Yan, Jiachao Zhang, Zhiyong Yan. (2023) Treatment of amoxicillin-containing wastewater by Trichoderma strains selected from activated sludge. SCIENCE OF THE TOTAL ENVIRONMENT, 867 (161565). [PMID:36642266] [10.1016/j.scitotenv.2023.161565] |
34. Chang Sun, Jian Lu, Yilin Wu, Minjia Meng, Chao Yu, Zeqing Dong, Muning Chen, Yongsheng Yan, Yan Sun. (2020) Imitated Core-Shell Molecularly Imprinted Membranes for Selective Separation Applications: A Synergetic Strategy by Polydopamine and SiO2. Journal of the Taiwan Institute of Chemical Engineers, 115 (304). [10.1016/j.jtice.2020.10.016] |
35. Yanyan Zhao, Huanxian Shi, Xiaoyun Hu, Enzhou Liu, Jun Fan. (2020) Fabricating CsPbX3/CN heterostructures with enhanced photocatalytic activity for penicillins 6-APA degradation. CHEMICAL ENGINEERING JOURNAL, 381 (122692). [10.1016/j.cej.2019.122692] |
36. Zhang Xiao-Li, Zong Min-Hua, Li Ning. (2016) Penicillin acylase-catalyzed synthesis of N-bromoacetyl-7-aminocephalosporanic acid, the key intermediate for the production of cefathiamidine. Bioresources and Bioprocessing, 3 (1): (1-8). [PMID:27917366] [10.1186/s40643-016-0127-3] |
37. Yuan-Ting Li, Lu-Lu Qu, Da-Wei Li, Qi-Xia Song, Farkhondeh Fathi, Yi-Tao Long. (2013) Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag–graphene sensor based on electrophoretic preconcentration and surface-enhanced Raman spectroscopy. BIOSENSORS & BIOELECTRONICS, 43 (94). [PMID:23287654] [10.1016/j.bios.2012.12.005] |