6-氨基青霉烷酸

  • ≥98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
A101337-5g
5g 现货 Stock Image
A101337-25g
25g 现货 Stock Image
A101337-100g
100g 现货 Stock Image
A101337-500g
500g 现货 Stock Image
A101337-2.5kg
2.5kg 现货 Stock Image

基本描述

别名 6-氨基青霉素酸
英文别名 FLUCLOXACILLIN SODIUM MONOHYDRATE IMPURITY C [EP IMPURITY] | PHENOXYMETHYLPENICILLIN IMPURITY C [EP IMPURITY] | SR-01000640154-1 | Flucloxacillin impurity C, European Pharmacopoeia (EP) Reference Standard | NSC-50071 | SULBACTAM SODIUM IMPURITY B [EP IMPU
规格或纯度 ≥98%
英文名称 (+)-6-Aminopenicillanic acid
应用 制备半合成青霉素的原料。
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

微溶于水,不溶于乙酸丁酯、乙醇或丙酮。遇碱分解,对酸较稳定。

AI解读

关联靶点(人)

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC22A8 Tclin Solute carrier family 22 member 8 (241 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Proteus mirabilis (3894 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus mutans (2687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc15a2 Oligopeptide transporter, kidney isoform (114 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc22a6 Solute carrier family 22 member 6 (141 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
mecA MecA (155 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504752056
EC号 208-993-4
分子类型 小分子
IUPAC Name (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
INCHI InChI=1S/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1
InChi Key NGHVIOIJCVXTGV-ALEPSDHESA-N
Canonical SMILES CC1(C(N2C(S1)C(C2=O)N)C(=O)O)C
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N)C(=O)O)C
WGK Germany 2
RTECS XH8225000
PubChem CID 11082
分子量 216.26
Beilstein号 15080
Reaxy-Rn 15080

化学和物理性质

密度 1.52
比旋光度 275° (C=1.2,0.1mol/L HCl)
熔点 198-200°C
分子量 216.260 g/mol
XLogP3 -2.100
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 216.057 Da
单同位素质量Monoisotopic Mass 216.057 Da
拓扑极表面积Topological Polar Surface Area 109.000 Ų
重原子数Heavy Atom Count 14
形式电荷Formal Charge 0
复杂度Complexity 318.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 3
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS08
信号词 Danger
危险声明

H317: 可能引起皮肤过敏反应

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P342+P311: 如有呼吸系统病症:呼叫急救中心/医生。

P302+P352: 如皮肤沾染:用水充分清洗。

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P403: 存放在通风良好的地方。

P270: 使用本产品时,请勿进食、饮水或吸烟。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。

P330: 漱口

P285: 如果通风不良,请佩戴呼吸防护装置。

P304+P341: 如果吸入:如果呼吸困难,请将患者转移到新鲜空气处并保持呼吸舒适的休息姿势。

P301+P312: 如误吞咽:如感觉不适,呼叫急救中心/医生。

WGK Germany 2
RTECS XH8225000
Reaxy-Rn 15080
Merck Index 458
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

技术规格说明书

Specific Rotation [a]20/D(c=1.2 in 0.1mol/L HCl) 270-280(°)
Melting point 197-200(℃)
Purity(HPLC) 98-100(%)
Purity(Neutralization titration) 97.5-102.5(%)
Appearance(A101337) White to yellow powder or crystals
Infrared spectrum Conforms to Structure
Solubility in 1 M HCl Almost transparency

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到8个结果

批号(Lot Number) 证书类型 日期 货号
J2418708 分析证书 24-04-02 A101337
F2425078 分析证书 24-04-02 A101337
D2016050 分析证书 24-01-30 A101337
B2321243 分析证书 23-02-27 A101337
B2321242 分析证书 23-02-27 A101337
B2321244 分析证书 23-02-27 A101337
L2219109 分析证书 22-12-22 A101337
E2506255 分析证书 21-05-28 A101337

此产品的引用文献

1. Yixiang Cai, Hong Yu, Liheng Ren, Yingjuan Ou, Shilin Jiang, Youzheng Chai, Anwei Chen, Binghua Yan, Jiachao Zhang, Zhiyong Yan.  (2023)  Treatment of amoxicillin-containing wastewater by Trichoderma strains selected from activated sludge.  SCIENCE OF THE TOTAL ENVIRONMENT,  867  (161565).  [PMID:36642266] [10.1016/j.scitotenv.2023.161565]
2. Chang Sun, Jian Lu, Yilin Wu, Minjia Meng, Chao Yu, Zeqing Dong, Muning Chen, Yongsheng Yan, Yan Sun.  (2020)  Imitated Core-Shell Molecularly Imprinted Membranes for Selective Separation Applications: A Synergetic Strategy by Polydopamine and SiO2.  Journal of the Taiwan Institute of Chemical Engineers,  115  (304).  [10.1016/j.jtice.2020.10.016]
3. Yanyan Zhao, Huanxian Shi, Xiaoyun Hu, Enzhou Liu, Jun Fan.  (2020)  Fabricating CsPbX3/CN heterostructures with enhanced photocatalytic activity for penicillins 6-APA degradation.  CHEMICAL ENGINEERING JOURNAL,  381  (122692).  [10.1016/j.cej.2019.122692]
4. Zhang Xiao-Li, Zong Min-Hua, Li Ning.  (2016)  Penicillin acylase-catalyzed synthesis of N-bromoacetyl-7-aminocephalosporanic acid, the key intermediate for the production of cefathiamidine.  Bioresources and Bioprocessing,  (1): (1-8).  [PMID:27917366] [10.1186/s40643-016-0127-3]
5. Yuan-Ting Li, Lu-Lu Qu, Da-Wei Li, Qi-Xia Song, Farkhondeh Fathi, Yi-Tao Long.  (2013)  Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag–graphene sensor based on electrophoretic preconcentration and surface-enhanced Raman spectroscopy.  BIOSENSORS & BIOELECTRONICS,  43  (94).  [PMID:23287654] [10.1016/j.bios.2012.12.005]

参考文献

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3. Yangyang Jiang,Hansong Xia,Chen Guo,Iram Mahmood,Huizhou Liu.  (2008-05-06)  Enzymatic hydrolysis of penicillin for 6-APA production in three-liquid-phase system..  Applied biochemistry and biotechnology,  144  ((2)): (145-159).  [PMID:18456946]
4. Weihua Song,Weisang Chen,William J Cooper,John Greaves,George E Miller.  (2008-07-22)  Free-radical destruction of beta-lactam antibiotics in aqueous solution..  The journal of physical chemistry. A,  112  ((32)): (7411-7417).  [PMID:18637660]
5. Rubina Arshad,Shafqat Farooq,Syed Shahid Ali.  (2008-12-19)  Comparative production of 6-aminopenicillanic acid by different E. coli strains and their acridine orange (AO) induced mutants..  Pakistan journal of biological sciences : PJBS,  10  ((21)): (3931-3935).  [PMID:19090257]
6. Louis Anthony Tony Cox,Douglas A Popken,Jeremy J Mathers.  (2009-06-06)  Human health risk assessment of penicillin/aminopenicillin resistance in enterococci due to penicillin use in food animals..  Risk analysis : an official publication of the Society for Risk Analysis,  29  ((6)): (796-805).  [PMID:19490520]
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9. Ye-Wang Zhang,Rui-Jiang Liu,Xi-Ming Xu.  (2010-06-23)  One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+..  Applied microbiology and biotechnology,  88  ((1)): (49-55).  [PMID:20567815]
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11. Junqi Zhao,Yujun Wang,Guangsheng Luo,Shenlin Zhu.  (2010-10-23)  Immobilization of penicillin G acylase on macro-mesoporous silica spheres..  Bioresource technology,  102  ((2)): (529-535).  [PMID:20965720]
12. Zhiqiang Chen,Hongcheng Wang,Zhaobo Chen,Nanqi Ren,Aijie Wang,Yue Shi,Xiaoming Li.  (2010-10-26)  Performance and model of a full-scale up-flow anaerobic sludge blanket (UASB) to treat the pharmaceutical wastewater containing 6-APA and amoxicillin..  Journal of hazardous materials,  185  ((2-3)): (905-913).  [PMID:20970923]
13. J-L Schmutz,A Barbaud,P Trechot.  (2011-05-17)  [Four recurrences of acute generalized exanthematous pustulosis (AGEP) with three different drugs in the same patient]..  Annales de dermatologie et de venereologie,  138  ((5)): (456-456).  [PMID:21570578]
14. V B Kurochkina,A V Sklyarenko,J E Satarova,S V Yarotsky.  (2011-06-24)  Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins..  Bioprocess and biosystems engineering,  34  ((9)): (1103-1117).  [PMID:21698348]
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18. Lucie Vobecká,Alexandr Romanov,Zdeněk Slouka,Pavel Hasal,Michal Přibyl.  (2018-04-04)  Optimization of aqueous two-phase systems for the production of 6-aminopenicillanic acid in integrated microfluidic reactors-separators..  New biotechnology,  47  (73-79).  [PMID:29614323]
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32. Guolin Li,Cen Xie,Siyu Lu,Robert G Nichols,Yuan Tian,Licen Li,Daxeshkumar Patel,Yinyan Ma,Chad N Brocker,Tingting Yan,Kristopher W Krausz,Rong Xiang,Oksana Gavrilova,Andrew D Patterson,Frank J Gonzalez.  (2017-09-19)  Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut\xa0Microbiota..  Cell metabolism,  26  ((4)): (672-685).  [PMID:28918936]
33. Yixiang Cai, Hong Yu, Liheng Ren, Yingjuan Ou, Shilin Jiang, Youzheng Chai, Anwei Chen, Binghua Yan, Jiachao Zhang, Zhiyong Yan.  (2023)  Treatment of amoxicillin-containing wastewater by Trichoderma strains selected from activated sludge.  SCIENCE OF THE TOTAL ENVIRONMENT,  867  (161565).  [PMID:36642266] [10.1016/j.scitotenv.2023.161565]
34. Chang Sun, Jian Lu, Yilin Wu, Minjia Meng, Chao Yu, Zeqing Dong, Muning Chen, Yongsheng Yan, Yan Sun.  (2020)  Imitated Core-Shell Molecularly Imprinted Membranes for Selective Separation Applications: A Synergetic Strategy by Polydopamine and SiO2.  Journal of the Taiwan Institute of Chemical Engineers,  115  (304).  [10.1016/j.jtice.2020.10.016]
35. Yanyan Zhao, Huanxian Shi, Xiaoyun Hu, Enzhou Liu, Jun Fan.  (2020)  Fabricating CsPbX3/CN heterostructures with enhanced photocatalytic activity for penicillins 6-APA degradation.  CHEMICAL ENGINEERING JOURNAL,  381  (122692).  [10.1016/j.cej.2019.122692]
36. Zhang Xiao-Li, Zong Min-Hua, Li Ning.  (2016)  Penicillin acylase-catalyzed synthesis of N-bromoacetyl-7-aminocephalosporanic acid, the key intermediate for the production of cefathiamidine.  Bioresources and Bioprocessing,  (1): (1-8).  [PMID:27917366] [10.1186/s40643-016-0127-3]
37. Yuan-Ting Li, Lu-Lu Qu, Da-Wei Li, Qi-Xia Song, Farkhondeh Fathi, Yi-Tao Long.  (2013)  Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag–graphene sensor based on electrophoretic preconcentration and surface-enhanced Raman spectroscopy.  BIOSENSORS & BIOELECTRONICS,  43  (94).  [PMID:23287654] [10.1016/j.bios.2012.12.005]

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